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LEFTY2

GENERAL INFORMATION

Gene name

 LEFTY2

Gene description

 Left-right determination factor 2

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (endometrium, smooth muscle)
GTEx:Group enriched (cervix, uterine, endometrium, ovary)
FANTOM5:Tissue enhanced (endometrium, ovary)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in smooth muscle. Extracellular positivity in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 3 antibodies.
HPA047883 , HPA056210 , CAB025801
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (endometrium, smooth muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, endometrium, ovary)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium, ovary)

GENE INFORMATION

Gene name

 LEFTY2 (HGNC Symbol)

Synonyms

 EBAF, LEFTA, LEFTYA, TGFB4

Description

 Left-right determination factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Chromosome

 1

Cytoband

 q42.12

Chromosome location (bp)

 225936598 - 225941489

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143768 (version 83.38)

Entrez gene

 7044

UniProt

 O00292 (UniProt - Evidence at protein level)

neXtProt

 NX_O00292

Antibodypedia

 LEFTY2 antibodies

PROTEIN BROWSER
LEFTY2-001
LEFTY2-201
LEFTY2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LEFTY2-001
ENSP00000355785
ENST00000366820
O00292 [Direct mapping]
Left-right determination factor 2
A0A024R3P5 [Target identity:100%; Query identity:100%]
Left-right determination factor 2, isoform CRA_a
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0002576 [platelet degranulation]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0030168 [platelet activation]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 366 aa
40.9 kDa 		Yes 0
LEFTY2-201
ENSP00000388009
ENST00000420304
O00292 [Direct mapping]
Left-right determination factor 2
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Show all
GO:0002576 [platelet degranulation]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0007596 [blood coagulation]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0030168 [platelet activation]
GO:0031012 [extracellular matrix]
GO:0031093 [platelet alpha granule lumen]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 332 aa
37.1 kDa 		Yes 0
LEFTY2-202
ENSP00000484300
ENST00000616737
A0A087X1L7 [Direct mapping]
Left-right determination factor 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016049 [cell growth]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
 372 aa
41.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.