We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000715 [nucleotide-excision repair, DNA damage recognition] GO:0000723 [telomere maintenance] GO:0000724 [double-strand break repair via homologous recombination] GO:0000784 [nuclear chromosome, telomeric region] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003950 [NAD+ ADP-ribosyltransferase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005730 [nucleolus] GO:0005739 [mitochondrion] GO:0006259 [DNA metabolic process] GO:0006281 [DNA repair] GO:0006284 [base-excision repair] GO:0006289 [nucleotide-excision repair] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006471 [protein ADP-ribosylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0007005 [mitochondrion organization] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010613 [positive regulation of cardiac muscle hypertrophy] GO:0016020 [membrane] GO:0016540 [protein autoprocessing] GO:0016925 [protein sumoylation] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030225 [macrophage differentiation] GO:0032042 [mitochondrial DNA metabolic process] GO:0032869 [cellular response to insulin stimulus] GO:0033683 [nucleotide-excision repair, DNA incision] GO:0034599 [cellular response to oxidative stress] GO:0036211 [protein modification process] GO:0040009 [regulation of growth rate] GO:0042769 [DNA damage response, detection of DNA damage] GO:0042802 [identical protein binding] GO:0042826 [histone deacetylase binding] GO:0043234 [protein complex] GO:0043504 [mitochondrial DNA repair] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0047485 [protein N-terminus binding] GO:0048148 [behavioral response to cocaine] GO:0051287 [NAD binding] GO:0060391 [positive regulation of SMAD protein import into nucleus] GO:0070212 [protein poly-ADP-ribosylation] GO:0070412 [R-SMAD binding] GO:0070911 [global genome nucleotide-excision repair] GO:0071451 [cellular response to superoxide] GO:1903516 [regulation of single strand break repair] GO:1903827 [regulation of cellular protein localization] GO:1990404 [protein ADP-ribosylase activity] GO:2000679 [positive regulation of transcription regulatory region DNA binding]