Expression of GALM in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GALM
Gene description	Galactose mutarotase (aldose 1-epimerase)
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, most abundant in renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA035472 , HPA035473
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035472	HPA035473

GENE INFORMATION
Gene name	GALM
Synonyms
Description	Galactose mutarotase (aldose 1-epimerase) (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the epimerization of hexose sugars such as glucose and galactose. The encoded protein is expressed in the cytoplasm and has a preference for galactose. The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose.[provided by RefSeq, Mar 2009]
Chromosome	2
Cytoband	p22.1
Chromosome location (bp)	38665910 - 38741237
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143891 (version 83.38)
Entrez gene	130589
UniProt	Q96C23 (UniProt - Evidence at protein level)
neXtProt	NX_Q96C23
Antibodypedia	GALM antibodies

PROTEIN BROWSER

GALM-001	GALM-003	GALM-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GALM-001 ENSP00000272252 ENST00000272252	Q96C23 [Direct mapping] Aldose 1-epimerase Show all	Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004034 [aldose 1-epimerase activity] GO:0005737 [cytoplasm] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006012 [galactose metabolic process] GO:0016853 [isomerase activity] GO:0019318 [hexose metabolic process] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] Show all	342 aa 37.8 kDa	No	0
GALM-003 ENSP00000386233 ENST00000410063	B8ZZ75 [Direct mapping] Aldose 1-epimerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0016853 [isomerase activity] GO:0030246 [carbohydrate binding] Show all	194 aa 21.5 kDa	No	0
GALM-005 ENSP00000399473 ENST00000434934	H7C1B5 [Direct mapping] Aldose 1-epimerase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005975 [carbohydrate metabolic process] GO:0016853 [isomerase activity] GO:0030246 [carbohydrate binding] Show all	218 aa 24.3 kDa	No	0