Cell atlas - CDCA7 - The Human Protein Atlas

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CDCA7

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	CDCA7
Gene description	Cell division cycle associated 7
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & nucleoplasm.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported), Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA005565
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & nucleoplasm.

Main location

Nucleoplasm (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA005565	A-431	Nucleoplasm	Intensity
	HPA005565	A-431	Cytosol
	HPA005565	U-2 OS	Nucleoplasm	Intensity	Intensity
	HPA005565	U-2 OS	Cytosol
	HPA005565	U-251 MG	Nucleoplasm	Intensity
	HPA005565	U-251 MG	Cytosol

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA005565	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. CDCA7 is mostly expressed at the G1/S checkpoint, and during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Nucleoplasm

GENE INFORMATION
Gene name	CDCA7 (HGNC Symbol)
Synonyms	FLJ14736, JPO1
Description	Cell division cycle associated 7 (HGNC Symbol)
Entrez gene summary	This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	173354820 - 173368997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144354 (version 83.38)
Entrez gene	83879
UniProt	Q9BWT1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWT1
Antibodypedia	CDCA7 antibodies

PROTEIN BROWSER

CDCA7-001	CDCA7-002	CDCA7-003	CDCA7-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CDCA7-001 ENSP00000306968 ENST00000306721	Q9BWT1 [Direct mapping] Cell division cycle-associated protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0042127 [regulation of cell proliferation] Show all	450 aa 51.4 kDa	No	0
CDCA7-002 ENSP00000272789 ENST00000347703	Q9BWT1 [Direct mapping] Cell division cycle-associated protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0042127 [regulation of cell proliferation] Show all	371 aa 42.6 kDa	No	0
CDCA7-003 ENSP00000386656 ENST00000410101	Q9BWT1 [Direct mapping] Cell division cycle-associated protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0042127 [regulation of cell proliferation] Show all	406 aa 46.4 kDa	No	0
CDCA7-004 ENSP00000386833 ENST00000410019	Q9BWT1 [Direct mapping] Cell division cycle-associated protein 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006915 [apoptotic process] GO:0042127 [regulation of cell proliferation] Show all	329 aa 37.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.