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CDCA7

GENERAL INFORMATION

Gene name

 CDCA7

Gene description

 Cell division cycle associated 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA005565
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and melanoma (unfavourable).
Liver cancer p<0.001
Melanoma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005565

GENE INFORMATION

Gene name

 CDCA7 (HGNC Symbol)

Synonyms

 FLJ14736, JPO1

Description

 Cell division cycle associated 7 (HGNC Symbol)

Entrez gene summary

 This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 173354820 - 173368997

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144354 (version 83.38)

Entrez gene

 83879

UniProt

 Q9BWT1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BWT1

Antibodypedia

 CDCA7 antibodies

PROTEIN BROWSER
CDCA7-001
CDCA7-002
CDCA7-003
CDCA7-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDCA7-001
ENSP00000306968
ENST00000306721
Q9BWT1 [Direct mapping]
Cell division cycle-associated protein 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0042127 [regulation of cell proliferation]
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 450 aa
51.4 kDa 		No 0
CDCA7-002
ENSP00000272789
ENST00000347703
Q9BWT1 [Direct mapping]
Cell division cycle-associated protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0042127 [regulation of cell proliferation]
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 371 aa
42.6 kDa 		No 0
CDCA7-003
ENSP00000386656
ENST00000410101
Q9BWT1 [Direct mapping]
Cell division cycle-associated protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0042127 [regulation of cell proliferation]
Show all
 406 aa
46.4 kDa 		No 0
CDCA7-004
ENSP00000386833
ENST00000410019
Q9BWT1 [Direct mapping]
Cell division cycle-associated protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0042127 [regulation of cell proliferation]
Show all
 329 aa
37.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.