Expression of ACKR3 in cancer - Summary

GENERAL INFORMATION
Gene name	ACKR3
Gene description	Atypical chemokine receptor 3
Protein class	Cancer-related genes G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RT4, SiHa, U-2197)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several different cell types, including trophoblasts and immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA049718
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), stomach cancer (unfavourable), urothelial cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Urothelial cancer p<0.001 Cervical cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA049718

GENE INFORMATION
Gene name	ACKR3 (HGNC Symbol)
Synonyms	CMKOR1, CXCR7, GPR159, RDC1
Description	Atypical chemokine receptor 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q37.3
Chromosome location (bp)	236567787 - 236582358
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144476 (version 83.38)
Entrez gene	57007
UniProt	P25106 (UniProt - Evidence at protein level)
neXtProt	NX_P25106
Antibodypedia	ACKR3 antibodies

PROTEIN BROWSER

ACKR3-001	ACKR3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACKR3-001 ENSP00000272928 ENST00000272928	P25106 [Direct mapping] Atypical chemokine receptor 3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0001570 [vasculogenesis] GO:0002230 [positive regulation of defense response to virus by host] GO:0004930 [G-protein coupled receptor activity] GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0005905 [coated pit] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009986 [cell surface] GO:0015026 [coreceptor activity] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016494 [C-X-C chemokine receptor activity] GO:0019958 [C-X-C chemokine binding] GO:0031623 [receptor internalization] GO:0048471 [perinuclear region of cytoplasm] GO:0055037 [recycling endosome] GO:0070098 [chemokine-mediated signaling pathway] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1902230 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] Show all	362 aa 41.5 kDa	No	7
ACKR3-002 ENSP00000405945 ENST00000447924		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	211 aa 24.2 kDa	No	4