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IQSEC1

GENERAL INFORMATION

Gene name

 IQSEC1

Gene description

 IQ motif and Sec7 domain 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in many tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 2 antibodies.
HPA038143 , HPA038144
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IQSEC1 (HGNC Symbol)

Synonyms

 ARF-GEP100, BRAG2, GEP100, KIAA0763

Description

 IQ motif and Sec7 domain 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 p25.2

Chromosome location (bp)

 12897220 - 13073117

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144711 (version 83.38)

Entrez gene

 9922

UniProt

 Q6DN90 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6DN90

Antibodypedia

 IQSEC1 antibodies

PROTEIN BROWSER
IQSEC1-001
IQSEC1-002
IQSEC1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IQSEC1-001
ENSP00000273221
ENST00000273221
Q6DN90 [Direct mapping]
IQ motif and SEC7 domain-containing protein 1
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0008289 [lipid binding]
GO:0016020 [membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 963 aa
108.3 kDa 		No 0
IQSEC1-002
ENSP00000478001
ENST00000618604
A0A0C4DGT3 [Direct mapping]
IQ motif and SEC7 domain-containing protein 1
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0030036 [actin cytoskeleton organization]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 814 aa
92 kDa 		No 0
IQSEC1-003
ENSP00000480301
ENST00000613206
A0A087WWK8 [Direct mapping]
IQ motif and SEC7 domain-containing protein 1
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005086 [ARF guanyl-nucleotide exchange factor activity]
GO:0005515 [protein binding]
GO:0030036 [actin cytoskeleton organization]
GO:0032012 [regulation of ARF protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
Show all
 1114 aa
124.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.