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PLA1A

GENERAL INFORMATION

Gene name

 PLA1A

Gene description

 Phospholipase A1 member A

Protein class

 Predicted intracellular proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, melanoma, prostate cancer, renal cancer)
HPA (cell line):Cell line enriched (SK-MEL-30)
HPA (normal tissue):Tissue enhanced (epididymis, seminal vesicle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, melanoma, prostate cancer, renal cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PLA1A (HGNC Symbol)

Synonyms

 ps-PLA1

Description

 Phospholipase A1 member A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Chromosome

 3

Cytoband

 q13.33

Chromosome location (bp)

 119597842 - 119629811

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144837 (version 83.38)

Entrez gene

 51365

UniProt

 Q53H76 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q53H76

Antibodypedia

 PLA1A antibodies

PROTEIN BROWSER
PLA1A-001
PLA1A-002
PLA1A-003
PLA1A-004
PLA1A-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLA1A-001
ENSP00000273371
ENST00000273371
Q53H76 [Direct mapping]
Phospholipase A1 member A
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002080 [acrosomal membrane]
GO:0006629 [lipid metabolic process]
GO:0006658 [phosphatidylserine metabolic process]
GO:0008970 [phosphatidylcholine 1-acylhydrolase activity]
GO:0016042 [lipid catabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
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 456 aa
49.7 kDa 		Yes 0
PLA1A-002
ENSP00000420625
ENST00000488919
Q53H76 [Direct mapping]
Phospholipase A1 member A
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
GO:0006658 [phosphatidylserine metabolic process]
GO:0016042 [lipid catabolic process]
GO:0070062 [extracellular exosome]
Show all
 283 aa
31.3 kDa 		No 0
PLA1A-003
ENSP00000417326
ENST00000495992
Q53H76 [Direct mapping]
Phospholipase A1 member A
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006629 [lipid metabolic process]
GO:0006658 [phosphatidylserine metabolic process]
GO:0016042 [lipid catabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
GO:0070062 [extracellular exosome]
Show all
 440 aa
47.9 kDa 		Yes 0
PLA1A-004
ENSP00000418793
ENST00000494440
G5E9W0 [Direct mapping]
Phospholipase A1 member A; Phospholipase A1 member A, isoform CRA_b
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006629 [lipid metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 440 aa
48.1 kDa 		No 0
PLA1A-005
ENSP00000417295
ENST00000475963
H7C4H1 [Direct mapping]
Phospholipase A1 member A
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   THUMBUP predicted membrane proteins
   SignalP predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0008152 [metabolic process]
GO:0052689 [carboxylic ester hydrolase activity]
Show all
 224 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.