Tissue expression of PLA1A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PLA1A
Gene description	Phospholipase A1 member A
Protein class	Predicted intracellular proteins Predicted secreted proteins RAS pathway related proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (epididymis, seminal vesicle)
GTEx:	Mixed
FANTOM5:	Tissue enriched (seminal vesicle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (epididymis, seminal vesicle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (seminal vesicle)

GENE INFORMATION
Gene name	PLA1A (HGNC Symbol)
Synonyms	ps-PLA1
Description	Phospholipase A1 member A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Chromosome	3
Cytoband	q13.33
Chromosome location (bp)	119597842 - 119629811
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144837 (version 83.38)
Entrez gene	51365
UniProt	Q53H76 (UniProt - Evidence at transcript level)
neXtProt	NX_Q53H76
Antibodypedia	PLA1A antibodies

PROTEIN BROWSER

PLA1A-001	PLA1A-002	PLA1A-003	PLA1A-004	PLA1A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA1A-001 ENSP00000273371 ENST00000273371	Q53H76 [Direct mapping] Phospholipase A1 member A Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002080 [acrosomal membrane] GO:0006629 [lipid metabolic process] GO:0006658 [phosphatidylserine metabolic process] GO:0008970 [phosphatidylcholine 1-acylhydrolase activity] GO:0016042 [lipid catabolic process] GO:0052689 [carboxylic ester hydrolase activity] GO:0070062 [extracellular exosome] Show all	456 aa 49.7 kDa	Yes	0
PLA1A-002 ENSP00000420625 ENST00000488919	Q53H76 [Direct mapping] Phospholipase A1 member A Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0006658 [phosphatidylserine metabolic process] GO:0016042 [lipid catabolic process] GO:0070062 [extracellular exosome] Show all	283 aa 31.3 kDa	No	0
PLA1A-003 ENSP00000417326 ENST00000495992	Q53H76 [Direct mapping] Phospholipase A1 member A Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0006658 [phosphatidylserine metabolic process] GO:0016042 [lipid catabolic process] GO:0052689 [carboxylic ester hydrolase activity] GO:0070062 [extracellular exosome] Show all	440 aa 47.9 kDa	Yes	0
PLA1A-004 ENSP00000418793 ENST00000494440	G5E9W0 [Direct mapping] Phospholipase A1 member A; Phospholipase A1 member A, isoform CRA_b Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0006629 [lipid metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	440 aa 48.1 kDa	No	0
PLA1A-005 ENSP00000417295 ENST00000475963	H7C4H1 [Direct mapping] Phospholipase A1 member A Show all	THUMBUP predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] GO:0008152 [metabolic process] GO:0052689 [carboxylic ester hydrolase activity] Show all	224 aa 24.1 kDa	No	0