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ATG3

GENERAL INFORMATION

Gene name

 ATG3

Gene description

 Autophagy related 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression often with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA040471 , CAB037260
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), prostate cancer (unfavourable) and cervical cancer (favourable).
Liver cancer p<0.001
Prostate cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040471
CAB037260

GENE INFORMATION

Gene name

 ATG3 (HGNC Symbol)

Synonyms

 APG3L, DKFZp564M1178, FLJ22125, MGC15201, PC3-96

Description

 Autophagy related 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

 3

Cytoband

 q13.2

Chromosome location (bp)

 112532509 - 112562046

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144848 (version 83.38)

Entrez gene

 64422

UniProt

 Q9NT62 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NT62

Antibodypedia

 ATG3 antibodies

PROTEIN BROWSER
ATG3-001
ATG3-003
ATG3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG3-001
ENSP00000283290
ENST00000283290
Q9NT62 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG3
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000045 [autophagosome assembly]
GO:0000153 [cytoplasmic ubiquitin ligase complex]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006612 [protein targeting to membrane]
GO:0006914 [autophagy]
GO:0016236 [macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019776 [Atg8 ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0019899 [enzyme binding]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044804 [nucleophagy]
GO:1902017 [regulation of cilium assembly]
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 314 aa
35.9 kDa 		No 0
ATG3-003
ENSP00000385943
ENST00000402314
Q9NT62 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG3
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000153 [cytoplasmic ubiquitin ligase complex]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006612 [protein targeting to membrane]
GO:0016236 [macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019776 [Atg8 ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0019899 [enzyme binding]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044804 [nucleophagy]
GO:1902017 [regulation of cilium assembly]
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 311 aa
35.5 kDa 		No 0
ATG3-005
ENSP00000420378
ENST00000492886
C9JNW8 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0019776 [Atg8 ligase activity]
GO:0044804 [nucleophagy]
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 83 aa
9.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.