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ATG3

GENERAL INFORMATION

Gene name

 ATG3

Gene description

 Autophagy related 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression often with a granular pattern in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA040471 , CAB037260
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ATG3 (HGNC Symbol)

Synonyms

 APG3L, DKFZp564M1178, FLJ22125, MGC15201, PC3-96

Description

 Autophagy related 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Chromosome

 3

Cytoband

 q13.2

Chromosome location (bp)

 112532509 - 112562046

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144848 (version 83.38)

Entrez gene

 64422

UniProt

 Q9NT62 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NT62

Antibodypedia

 ATG3 antibodies

PROTEIN BROWSER
ATG3-001
ATG3-003
ATG3-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG3-001
ENSP00000283290
ENST00000283290
Q9NT62 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG3
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000153 [cytoplasmic ubiquitin ligase complex]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006612 [protein targeting to membrane]
GO:0006914 [autophagy]
GO:0016236 [macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019776 [Atg8 ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0019899 [enzyme binding]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044804 [nucleophagy]
GO:1902017 [regulation of cilium assembly]
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 314 aa
35.9 kDa 		No 0
ATG3-003
ENSP00000385943
ENST00000402314
Q9NT62 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG3
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000153 [cytoplasmic ubiquitin ligase complex]
GO:0000422 [mitophagy]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006464 [cellular protein modification process]
GO:0006612 [protein targeting to membrane]
GO:0016236 [macroautophagy]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019776 [Atg8 ligase activity]
GO:0019777 [Atg12 transferase activity]
GO:0019787 [ubiquitin-like protein transferase activity]
GO:0019899 [enzyme binding]
GO:0043653 [mitochondrial fragmentation involved in apoptotic process]
GO:0044804 [nucleophagy]
GO:1902017 [regulation of cilium assembly]
Show all
 311 aa
35.5 kDa 		No 0
ATG3-005
ENSP00000420378
ENST00000492886
C9JNW8 [Direct mapping]
Ubiquitin-like-conjugating enzyme ATG3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0019776 [Atg8 ligase activity]
GO:0044804 [nucleophagy]
Show all
 83 aa
9.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.