Cell atlas - MED12L - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MED12L

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	MED12L
Gene description	Mediator complex subunit 12-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Cell line enhanced (HEL, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036807
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036807	A-431	Nucleoli
	HPA036807	U-2 OS	Nucleoli
	HPA036807	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	MED12L (HGNC Symbol)
Synonyms	KIAA1635, TNRC11L, TRALP, TRALPUSH
Description	Mediator complex subunit 12-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	151085697 - 151437072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144893 (version 83.38)
Entrez gene	116931
UniProt	Q86YW9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YW9
Antibodypedia	MED12L antibodies

PROTEIN BROWSER

MED12L-001	MED12L-002	MED12L-004	MED12L-005	MED12L-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED12L-001 ENSP00000417235 ENST00000474524	Q86YW9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	2145 aa 240.1 kDa	No	0
MED12L-002 ENSP00000310760 ENST00000309237	Q86YW9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	756 aa 85 kDa	No	0
MED12L-004 ENSP00000403308 ENST00000422248	Q86YW9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	721 aa 81.1 kDa	No	0
MED12L-005 ENSP00000273432 ENST00000273432	F8WAE6 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	1809 aa 203.8 kDa	No	0
MED12L-007 ENSP00000417420 ENST00000480026	H7C4I9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	74 aa 8.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.