Expression of MED12L in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MED12L

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MED12L
Gene description	Mediator complex subunit 12-like
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, HEL)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expressed in testis and brain.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA036807
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036807

GENE INFORMATION
Gene name	MED12L (HGNC Symbol)
Synonyms	KIAA1635, TNRC11L, TRALP, TRALPUSH
Description	Mediator complex subunit 12-like (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
Chromosome	3
Cytoband	q25.1
Chromosome location (bp)	151085697 - 151437072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144893 (version 83.38)
Entrez gene	116931
UniProt	Q86YW9 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YW9
Antibodypedia	MED12L antibodies

PROTEIN BROWSER

MED12L-001	MED12L-002	MED12L-004	MED12L-005	MED12L-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED12L-001 ENSP00000417235 ENST00000474524	Q86YW9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	2145 aa 240.1 kDa	No	0
MED12L-002 ENSP00000310760 ENST00000309237	Q86YW9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	756 aa 85 kDa	No	0
MED12L-004 ENSP00000403308 ENST00000422248	Q86YW9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0001105 [RNA polymerase II transcription coactivator activity] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	721 aa 81.1 kDa	No	0
MED12L-005 ENSP00000273432 ENST00000273432	F8WAE6 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008013 [beta-catenin binding] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	1809 aa 203.8 kDa	No	0
MED12L-007 ENSP00000417420 ENST00000480026	H7C4I9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12-like protein Show all	Predicted intracellular proteins Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0016592 [mediator complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	74 aa 8.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.