Cell atlas - AHSG - The Human Protein Atlas

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AHSG

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	AHSG
Gene description	Alpha-2-HS-glycoprotein
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enriched (Hep G2)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA001524 , HPA001525
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (Hep G2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001524	Hep G2	Golgi apparatus
	HPA001525	Hep G2	Golgi apparatus

GENE INFORMATION
Gene name	AHSG (HGNC Symbol)
Synonyms	A2HS, FETUA, HSGA
Description	Alpha-2-HS-glycoprotein (HGNC Symbol)
Entrez gene summary	Alpha2-HS glycoprotein (AHSG), a glycoprotein present in the serum, is synthesized by hepatocytes. The AHSG molecule consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. The protein is commonly present in the cortical plate of the immature cerebral cortex and bone marrow hemopoietic matrix, and it has therefore been postulated that it participates in the development of the tissues. However, its exact significance is still obscure. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q27.3
Chromosome location (bp)	186612923 - 186621318
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145192 (version 83.38)
Entrez gene	197
UniProt	P02765 (UniProt - Evidence at protein level)
neXtProt	NX_P02765
Antibodypedia	AHSG antibodies

PROTEIN BROWSER

AHSG-001	AHSG-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AHSG-001 ENSP00000393887 ENST00000411641	P02765 [Direct mapping] Alpha-2-HS-glycoprotein Alpha-2-HS-glycoprotein chain A Alpha-2-HS-glycoprotein chain B Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0001503 [ossification] GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006907 [pinocytosis] GO:0006953 [acute-phase response] GO:0010951 [negative regulation of endopeptidase activity] GO:0019210 [kinase inhibitor activity] GO:0030500 [regulation of bone mineralization] GO:0030502 [negative regulation of bone mineralization] GO:0042326 [negative regulation of phosphorylation] GO:0046627 [negative regulation of insulin receptor signaling pathway] GO:0050727 [regulation of inflammatory response] GO:0050766 [positive regulation of phagocytosis] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	367 aa 39.3 kDa	Yes	0
AHSG-002 ENSP00000273784 ENST00000273784	C9JV77 [Direct mapping] Alpha-2-HS-glycoprotein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004869 [cysteine-type endopeptidase inhibitor activity] GO:0005615 [extracellular space] GO:0010951 [negative regulation of endopeptidase activity] Show all	368 aa 39.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.