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SLC26A1

GENERAL INFORMATION

Gene name

 SLC26A1

Gene description

 Solute carrier family 26 (anion exchanger), member 1

Protein class

 Plasma proteins
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041654
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041654

GENE INFORMATION

Gene name

 SLC26A1 (HGNC Symbol)

Synonyms

 EDM4, SAT-1

Description

 Solute carrier family 26 (anion exchanger), member 1 (HGNC Symbol)

Entrez gene summary

 This gene is a member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures, but have markedly different tissue expression patterns. This gene is primarily expressed in the liver, pancreas, and brain. Three splice variants that encode different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p16.3

Chromosome location (bp)

 979073 - 993440

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145217 (version 83.38)

Entrez gene

 10861

UniProt

 Q9H2B4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2B4

Antibodypedia

 SLC26A1 antibodies

PROTEIN BROWSER
SLC26A1-001
SLC26A1-002
SLC26A1-003
SLC26A1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC26A1-001
ENSP00000354721
ENST00000361661
Q9H2B4 [Direct mapping]
Sulfate anion transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0042391 [regulation of membrane potential]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 701 aa
75 kDa 		No >9
SLC26A1-002
ENSP00000381528
ENST00000398516
Q9H2B4 [Direct mapping]
Sulfate anion transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015701 [bicarbonate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0042391 [regulation of membrane potential]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 701 aa
75 kDa 		No >9
SLC26A1-003
ENSP00000381532
ENST00000398520
Q9H2B4 [Direct mapping]
Sulfate anion transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015701 [bicarbonate transport]
GO:0016021 [integral component of membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0042391 [regulation of membrane potential]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 224 aa
25 kDa 		No 3
SLC26A1-201
ENSP00000483506
ENST00000622731
Q9H2B4 [Direct mapping]
Sulfate anion transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015701 [bicarbonate transport]
GO:0016021 [integral component of membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0042391 [regulation of membrane potential]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
GO:0051453 [regulation of intracellular pH]
GO:0055085 [transmembrane transport]
GO:1902358 [sulfate transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 224 aa
25 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.