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KLHL8

GENERAL INFORMATION

Gene name

 KLHL8

Gene description

 Kelch-like family member 8

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA013856 , HPA017762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA013856
HPA017762

GENE INFORMATION

Gene name

 KLHL8 (HGNC Symbol)

Synonyms

 KIAA1378

Description

 Kelch-like family member 8 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q22.1

Chromosome location (bp)

 87160103 - 87240314

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145332 (version 83.38)

Entrez gene

 57563

UniProt

 Q9P2G9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P2G9

Antibodypedia

 KLHL8 antibodies

PROTEIN BROWSER
KLHL8-001
KLHL8-002
KLHL8-003
KLHL8-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLHL8-001
ENSP00000273963
ENST00000273963
Q9P2G9 [Direct mapping]
Kelch-like protein 8
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
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 620 aa
68.8 kDa 		No 0
KLHL8-002
ENSP00000426451
ENST00000498875
Q9P2G9 [Direct mapping]
Kelch-like protein 8
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 544 aa
60.3 kDa 		No 0
KLHL8-003
ENSP00000408854
ENST00000425278
Q68DU9 [Direct mapping]
Kelch-like protein 8; Putative uncharacterized protein DKFZp781C1855
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
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 437 aa
48 kDa 		No 0
KLHL8-005
ENSP00000424131
ENST00000512111
Q9P2G9 [Direct mapping]
Kelch-like protein 8
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0016567 [protein ubiquitination]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
Show all
 620 aa
68.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.