Cell atlas - CISD2 - The Human Protein Atlas

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CISD2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Endoplasmic reticulum

Human cell
	Endoplasmic Reticulum

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GENERAL INFORMATION
Gene name	CISD2
Gene description	CDGSH iron sulfur domain 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the endoplasmic reticulum.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Endoplasmic reticulum (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA015914
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the endoplasmic reticulum.

Main location

Endoplasmic reticulum (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015914	A-431	Endoplasmic reticulum
	HPA015914	U-2 OS	No staining
	HPA015914	U-251 MG	Endoplasmic reticulum

GENE INFORMATION
Gene name	CISD2 (HGNC Symbol)
Synonyms	ERIS, Miner1, NAF-1, WFS2, ZCD2
Description	CDGSH iron sulfur domain 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	102868978 - 102889242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145354 (version 83.38)
Entrez gene	493856
UniProt	Q8N5K1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5K1
Antibodypedia	CISD2 antibodies

PROTEIN BROWSER

CISD2-001	CISD2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CISD2-001 ENSP00000273986 ENST00000273986	Q8N5K1 [Direct mapping] CDGSH iron-sulfur domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000422 [mitophagy] GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0010259 [multicellular organismal aging] GO:0010506 [regulation of autophagy] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0051537 [2 iron, 2 sulfur cluster binding] Show all	135 aa 15.3 kDa	No	1
CISD2-002 ENSP00000423716 ENST00000503643	D6RCF4 [Direct mapping] CDGSH iron-sulfur domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0051537 [2 iron, 2 sulfur cluster binding] Show all	145 aa 16.1 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.