Expression of CISD2 in cancer - Summary - The Human Protein Atlas

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CISD2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CISD2
Gene description	CDGSH iron sulfur domain 2
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA015914
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015914

GENE INFORMATION
Gene name	CISD2 (HGNC Symbol)
Synonyms	ERIS, Miner1, NAF-1, WFS2, ZCD2
Description	CDGSH iron sulfur domain 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Chromosome	4
Cytoband	q24
Chromosome location (bp)	102868978 - 102889242
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145354 (version 83.38)
Entrez gene	493856
UniProt	Q8N5K1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N5K1
Antibodypedia	CISD2 antibodies

PROTEIN BROWSER

CISD2-001	CISD2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CISD2-001 ENSP00000273986 ENST00000273986	Q8N5K1 [Direct mapping] CDGSH iron-sulfur domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000422 [mitophagy] GO:0005515 [protein binding] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0010259 [multicellular organismal aging] GO:0010506 [regulation of autophagy] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042803 [protein homodimerization activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0043234 [protein complex] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0051537 [2 iron, 2 sulfur cluster binding] Show all	135 aa 15.3 kDa	No	1
CISD2-002 ENSP00000423716 ENST00000503643	D6RCF4 [Direct mapping] CDGSH iron-sulfur domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0051537 [2 iron, 2 sulfur cluster binding] Show all	145 aa 16.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.