Expression of USP53 in cancer - Summary - The Human Protein Atlas

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USP53

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	USP53
Gene description	Ubiquitin specific peptidase 53
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+, SK-MEL-30)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in many tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA035844 , HPA035845
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), colorectal cancer (favourable) and prostate cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Prostate cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035844	HPA035845

GENE INFORMATION
Gene name	USP53 (HGNC Symbol)
Synonyms	KIAA1350
Description	Ubiquitin specific peptidase 53 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q26
Chromosome location (bp)	119212587 - 119295517
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145390 (version 83.38)
Entrez gene	54532
UniProt	Q70EK8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q70EK8
Antibodypedia	USP53 antibodies

PROTEIN BROWSER

USP53-001	USP53-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP53-001 ENSP00000274030 ENST00000274030	Q70EK8 [Direct mapping] Inactive ubiquitin carboxyl-terminal hydrolase 53 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] Show all	1073 aa 120.8 kDa	No	0
USP53-201 ENSP00000409906 ENST00000450251	Q70EK8 [Direct mapping] Inactive ubiquitin carboxyl-terminal hydrolase 53 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] Show all	1073 aa 120.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.