Tissue expression of USP53 - Summary - The Human Protein Atlas

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USP53

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	USP53
Gene description	Ubiquitin specific peptidase 53
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly cytoplasmic expression in many tissues.

DATA RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA035844 , HPA035845
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	USP53 (HGNC Symbol)
Synonyms	KIAA1350
Description	Ubiquitin specific peptidase 53 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q26
Chromosome location (bp)	119212587 - 119295517
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145390 (version 83.38)
Entrez gene	54532
UniProt	Q70EK8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q70EK8
Antibodypedia	USP53 antibodies

PROTEIN BROWSER

USP53-001	USP53-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
USP53-001 ENSP00000274030 ENST00000274030	Q70EK8 [Direct mapping] Inactive ubiquitin carboxyl-terminal hydrolase 53 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] Show all	1073 aa 120.8 kDa	No	0
USP53-201 ENSP00000409906 ENST00000450251	Q70EK8 [Direct mapping] Inactive ubiquitin carboxyl-terminal hydrolase 53 Show all	Enzymes Peptidases Cysteine-type peptidases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005575 [cellular_component] GO:0008150 [biological_process] GO:0016579 [protein deubiquitination] GO:0036459 [ubiquitinyl hydrolase activity] Show all	1073 aa 120.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.