Cell atlas - BHMT - The Human Protein Atlas

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BHMT

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	BHMT
Gene description	Betaine--homocysteine S-methyltransferase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (Hep G2, NTERA-2, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA038285
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Hep G2, NTERA-2, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038285	A-431	Cytosol	Intensity
	HPA038285	U-2 OS	Cytosol
	HPA038285	U-251 MG	Cytosol

GENE INFORMATION
Gene name	BHMT (HGNC Symbol)
Synonyms	BHMT1
Description	Betaine--homocysteine S-methyltransferase (HGNC Symbol)
Entrez gene summary	This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q14.1
Chromosome location (bp)	79111779 - 79132290
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145692 (version 83.38)
Entrez gene	635
UniProt	Q93088 (UniProt - Evidence at protein level)
neXtProt	NX_Q93088
Antibodypedia	BHMT antibodies

PROTEIN BROWSER

BHMT-001	BHMT-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BHMT-001 ENSP00000274353 ENST00000274353	Q93088 [Direct mapping] Betaine--homocysteine S-methyltransferase 1 V9HWA4 [Target identity:100%; Query identity:100%] Betaine-homocysteine methyltransferase, isoform CRA_a; Epididymis secretory sperm binding protein Li 61p Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000096 [sulfur amino acid metabolic process] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006479 [protein methylation] GO:0006577 [amino-acid betaine metabolic process] GO:0006579 [amino-acid betaine catabolic process] GO:0008270 [zinc ion binding] GO:0008898 [S-adenosylmethionine-homocysteine S-methyltransferase activity] GO:0009086 [methionine biosynthetic process] GO:0033528 [S-methylmethionine cycle] GO:0034641 [cellular nitrogen compound metabolic process] GO:0044281 [small molecule metabolic process] GO:0047150 [betaine-homocysteine S-methyltransferase activity] GO:0050666 [regulation of homocysteine metabolic process] GO:0070062 [extracellular exosome] GO:0071267 [L-methionine salvage] Show all	406 aa 45 kDa	No	0
BHMT-003 ENSP00000428240 ENST00000524080	E5RJH0 [Direct mapping] Betaine--homocysteine S-methyltransferase 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0008270 [zinc ion binding] GO:0008898 [S-adenosylmethionine-homocysteine S-methyltransferase activity] GO:0009086 [methionine biosynthetic process] GO:0032259 [methylation] GO:0033528 [S-methylmethionine cycle] GO:0047150 [betaine-homocysteine S-methyltransferase activity] Show all	253 aa 28.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.