Fields »
ABOUT
HELP
BLOG
BHMT

GENERAL INFORMATION

Gene name

 BHMT

Gene description

 Betaine--homocysteine S-methyltransferase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer, renal cancer)
HPA (cell line):Cell line enhanced (Hep G2, NTERA-2, SCLC-21H)
HPA (normal tissue):Group enriched (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in hepatocytes and kidney tubules.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA038285 , HPA058310
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer, renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038285
HPA058310

GENE INFORMATION

Gene name

 BHMT (HGNC Symbol)

Synonyms

 BHMT1

Description

 Betaine--homocysteine S-methyltransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q14.1

Chromosome location (bp)

 79111779 - 79132290

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145692 (version 83.38)

Entrez gene

 635

UniProt

 Q93088 (UniProt - Evidence at protein level)

neXtProt

 NX_Q93088

Antibodypedia

 BHMT antibodies

PROTEIN BROWSER
BHMT-001
BHMT-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BHMT-001
ENSP00000274353
ENST00000274353
Q93088 [Direct mapping]
Betaine--homocysteine S-methyltransferase 1
V9HWA4 [Target identity:100%; Query identity:100%]
Betaine-homocysteine methyltransferase, isoform CRA_a; Epididymis secretory sperm binding protein Li 61p
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006479 [protein methylation]
GO:0006577 [amino-acid betaine metabolic process]
GO:0006579 [amino-acid betaine catabolic process]
GO:0008270 [zinc ion binding]
GO:0008898 [S-adenosylmethionine-homocysteine S-methyltransferase activity]
GO:0009086 [methionine biosynthetic process]
GO:0033528 [S-methylmethionine cycle]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0047150 [betaine-homocysteine S-methyltransferase activity]
GO:0050666 [regulation of homocysteine metabolic process]
GO:0070062 [extracellular exosome]
GO:0071267 [L-methionine salvage]
Show all
 406 aa
45 kDa 		No 0
BHMT-003
ENSP00000428240
ENST00000524080
E5RJH0 [Direct mapping]
Betaine--homocysteine S-methyltransferase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0008898 [S-adenosylmethionine-homocysteine S-methyltransferase activity]
GO:0009086 [methionine biosynthetic process]
GO:0032259 [methylation]
GO:0033528 [S-methylmethionine cycle]
GO:0047150 [betaine-homocysteine S-methyltransferase activity]
Show all
 253 aa
28.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.