Cell atlas - MEGF10 - The Human Protein Atlas

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MEGF10

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MEGF10
Gene description	Multiple EGF-like-domains 10
Protein class	Disease related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (RH-30, AF22)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RH-30, AF22) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MEGF10 (HGNC Symbol)
Synonyms	KIAA1780
Description	Multiple EGF-like-domains 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]
Chromosome	5
Cytoband	q23.2
Chromosome location (bp)	127290831 - 127465737
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145794 (version 83.38)
Entrez gene	84466
UniProt	Q96KG7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KG7
Antibodypedia	MEGF10 antibodies

PROTEIN BROWSER

MEGF10-001	MEGF10-002	MEGF10-003	MEGF10-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MEGF10-001 ENSP00000274473 ENST00000274473	Q96KG7 [Direct mapping] Multiple epidermal growth factor-like domains protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001891 [phagocytic cup] GO:0005515 [protein binding] GO:0014719 [skeletal muscle satellite cell activation] GO:0014816 [skeletal muscle satellite cell differentiation] GO:0014841 [skeletal muscle satellite cell proliferation] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0034109 [homotypic cell-cell adhesion] GO:0042995 [cell projection] GO:0043654 [recognition of apoptotic cell] GO:0048641 [regulation of skeletal muscle tissue development] GO:0051147 [regulation of muscle cell differentiation] GO:0055001 [muscle cell development] Show all	1140 aa 122.2 kDa	Yes	1
MEGF10-002 ENSP00000416284 ENST00000418761	Q96KG7 [Direct mapping] Multiple epidermal growth factor-like domains protein 10 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001891 [phagocytic cup] GO:0005515 [protein binding] GO:0014719 [skeletal muscle satellite cell activation] GO:0014816 [skeletal muscle satellite cell differentiation] GO:0014841 [skeletal muscle satellite cell proliferation] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0034109 [homotypic cell-cell adhesion] GO:0042995 [cell projection] GO:0048641 [regulation of skeletal muscle tissue development] GO:0051147 [regulation of muscle cell differentiation] GO:0055001 [muscle cell development] Show all	567 aa 60.8 kDa	Yes	0
MEGF10-003 ENSP00000423195 ENST00000508365	Q96KG7 [Direct mapping] Multiple epidermal growth factor-like domains protein 10 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001891 [phagocytic cup] GO:0005515 [protein binding] GO:0014719 [skeletal muscle satellite cell activation] GO:0014816 [skeletal muscle satellite cell differentiation] GO:0014841 [skeletal muscle satellite cell proliferation] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0034109 [homotypic cell-cell adhesion] GO:0042995 [cell projection] GO:0048641 [regulation of skeletal muscle tissue development] GO:0051147 [regulation of muscle cell differentiation] GO:0055001 [muscle cell development] Show all	567 aa 60.8 kDa	Yes	0
MEGF10-004 ENSP00000423354 ENST00000503335	Q96KG7 [Direct mapping] Multiple epidermal growth factor-like domains protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001891 [phagocytic cup] GO:0005515 [protein binding] GO:0014719 [skeletal muscle satellite cell activation] GO:0014816 [skeletal muscle satellite cell differentiation] GO:0014841 [skeletal muscle satellite cell proliferation] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0034109 [homotypic cell-cell adhesion] GO:0042995 [cell projection] GO:0048641 [regulation of skeletal muscle tissue development] GO:0051147 [regulation of muscle cell differentiation] GO:0055001 [muscle cell development] Show all	1140 aa 122.2 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.