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MEGF10

GENERAL INFORMATION

Gene name

 MEGF10

Gene description

 Multiple EGF-like-domains 10

Protein class

 Disease related genes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Group enriched (AF22, RH-30)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MEGF10 (HGNC Symbol)

Synonyms

 KIAA1780

Description

 Multiple EGF-like-domains 10 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 5

Cytoband

 q23.2

Chromosome location (bp)

 127290831 - 127465737

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145794 (version 83.38)

Entrez gene

 84466

UniProt

 Q96KG7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96KG7

Antibodypedia

 MEGF10 antibodies

PROTEIN BROWSER
MEGF10-001
MEGF10-002
MEGF10-003
MEGF10-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MEGF10-001
ENSP00000274473
ENST00000274473
Q96KG7 [Direct mapping]
Multiple epidermal growth factor-like domains protein 10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0005515 [protein binding]
GO:0014719 [skeletal muscle satellite cell activation]
GO:0014816 [skeletal muscle satellite cell differentiation]
GO:0014841 [skeletal muscle satellite cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042995 [cell projection]
GO:0043654 [recognition of apoptotic cell]
GO:0048641 [regulation of skeletal muscle tissue development]
GO:0051147 [regulation of muscle cell differentiation]
GO:0055001 [muscle cell development]
Show all
 1140 aa
122.2 kDa 		Yes 1
MEGF10-002
ENSP00000416284
ENST00000418761
Q96KG7 [Direct mapping]
Multiple epidermal growth factor-like domains protein 10
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0005515 [protein binding]
GO:0014719 [skeletal muscle satellite cell activation]
GO:0014816 [skeletal muscle satellite cell differentiation]
GO:0014841 [skeletal muscle satellite cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042995 [cell projection]
GO:0048641 [regulation of skeletal muscle tissue development]
GO:0051147 [regulation of muscle cell differentiation]
GO:0055001 [muscle cell development]
Show all
 567 aa
60.8 kDa 		Yes 0
MEGF10-003
ENSP00000423195
ENST00000508365
Q96KG7 [Direct mapping]
Multiple epidermal growth factor-like domains protein 10
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0005515 [protein binding]
GO:0014719 [skeletal muscle satellite cell activation]
GO:0014816 [skeletal muscle satellite cell differentiation]
GO:0014841 [skeletal muscle satellite cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042995 [cell projection]
GO:0048641 [regulation of skeletal muscle tissue development]
GO:0051147 [regulation of muscle cell differentiation]
GO:0055001 [muscle cell development]
Show all
 567 aa
60.8 kDa 		Yes 0
MEGF10-004
ENSP00000423354
ENST00000503335
Q96KG7 [Direct mapping]
Multiple epidermal growth factor-like domains protein 10
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001891 [phagocytic cup]
GO:0005515 [protein binding]
GO:0014719 [skeletal muscle satellite cell activation]
GO:0014816 [skeletal muscle satellite cell differentiation]
GO:0014841 [skeletal muscle satellite cell proliferation]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0034109 [homotypic cell-cell adhesion]
GO:0042995 [cell projection]
GO:0048641 [regulation of skeletal muscle tissue development]
GO:0051147 [regulation of muscle cell differentiation]
GO:0055001 [muscle cell development]
Show all
 1140 aa
122.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.