Cell atlas - ARHGAP26 - The Human Protein Atlas

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ARHGAP26

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ARHGAP26
Gene description	Rho GTPase activating protein 26
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (Karpas-707)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA035106
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035106	A-431	Cytosol
	HPA035106	U-2 OS	Cytosol
	HPA035106	U-251 MG	Cytosol

GENE INFORMATION
Gene name	ARHGAP26 (HGNC Symbol)
Synonyms	GRAF, KIAA0621, OPHN1L, OPHN1L1
Description	Rho GTPase activating protein 26 (HGNC Symbol)
Entrez gene summary	Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Chromosome	5
Cytoband	q31.3
Chromosome location (bp)	142770384 - 143229011
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145819 (version 83.38)
Entrez gene	23092
UniProt	Q9UNA1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UNA1
Antibodypedia	ARHGAP26 antibodies

PROTEIN BROWSER

ARHGAP26-001	ARHGAP26-008	ARHGAP26-009	ARHGAP26-012	ARHGAP26-013	ARHGAP26-014	ARHGAP26-015	ARHGAP26-020	ARHGAP26-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP26-001 ENSP00000274498 ENST00000274498	Q9UNA1 [Direct mapping] Rho GTPase-activating protein 26 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0007009 [plasma membrane organization] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	814 aa 92.2 kDa	No	0
ARHGAP26-008 ENSP00000367243 ENST00000378004	Q9UNA1 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005543 [phospholipid binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0005925 [focal adhesion] GO:0007009 [plasma membrane organization] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007399 [nervous system development] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	759 aa 86.2 kDa	No	0
ARHGAP26-009 ENSP00000392186 ENST00000443045	H7BZZ0 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0007165 [signal transduction] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	97 aa 10.9 kDa	No	0
ARHGAP26-012 ENSP00000389137 ENST00000421521	H7BZE1 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	154 aa 16.2 kDa	No	1
ARHGAP26-013 ENSP00000403388 ENST00000425417	H7C205 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	98 aa 10.1 kDa	No	0
ARHGAP26-014 ENSP00000367252 ENST00000378013	F8W8N5 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	166 aa 19.5 kDa	No	0
ARHGAP26-015 ENSP00000411571 ENST00000451259	C9J6V4 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	91 aa 10.2 kDa	No	0
ARHGAP26-020 ENSP00000416889 ENST00000418236	H0Y835 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	294 aa 32.8 kDa	No	0
ARHGAP26-021 ENSP00000393276 ENST00000443674	H0Y4P9 [Direct mapping] Rho GTPase-activating protein 26 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0030036 [actin cytoskeleton organization] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	388 aa 42.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.