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ARHGAP26

GENERAL INFORMATION

Gene name

 ARHGAP26

Gene description

 Rho GTPase activating protein 26

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (Karpas-707)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membrane expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA035106 , HPA035107
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), endometrial cancer (favourable), cervical cancer (favourable), breast cancer (favourable) and colorectal cancer (favourable).
Urothelial cancer p<0.001
Endometrial cancer p<0.001
Cervical cancer p<0.001
Breast cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035106
HPA035107

GENE INFORMATION

Gene name

 ARHGAP26 (HGNC Symbol)

Synonyms

 GRAF, KIAA0621, OPHN1L, OPHN1L1

Description

 Rho GTPase activating protein 26 (HGNC Symbol)

Entrez gene summary

 Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Chromosome

 5

Cytoband

 q31.3

Chromosome location (bp)

 142770384 - 143229011

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145819 (version 83.38)

Entrez gene

 23092

UniProt

 Q9UNA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNA1

Antibodypedia

 ARHGAP26 antibodies

PROTEIN BROWSER
ARHGAP26-001
ARHGAP26-008
ARHGAP26-009
ARHGAP26-012
ARHGAP26-013
ARHGAP26-014
ARHGAP26-015
ARHGAP26-020
ARHGAP26-021

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP26-001
ENSP00000274498
ENST00000274498
Q9UNA1 [Direct mapping]
Rho GTPase-activating protein 26
Show all
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007009 [plasma membrane organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 814 aa
92.2 kDa 		No 0
ARHGAP26-008
ENSP00000367243
ENST00000378004
Q9UNA1 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005575 [cellular_component]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005925 [focal adhesion]
GO:0007009 [plasma membrane organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007399 [nervous system development]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 759 aa
86.2 kDa 		No 0
ARHGAP26-009
ENSP00000392186
ENST00000443045
H7BZZ0 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0007165 [signal transduction]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 97 aa
10.9 kDa 		No 0
ARHGAP26-012
ENSP00000389137
ENST00000421521
H7BZE1 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 154 aa
16.2 kDa 		No 1
ARHGAP26-013
ENSP00000403388
ENST00000425417
H7C205 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 98 aa
10.1 kDa 		No 0
ARHGAP26-014
ENSP00000367252
ENST00000378013
F8W8N5 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 166 aa
19.5 kDa 		No 0
ARHGAP26-015
ENSP00000411571
ENST00000451259
C9J6V4 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 91 aa
10.2 kDa 		No 0
ARHGAP26-020
ENSP00000416889
ENST00000418236
H0Y835 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 294 aa
32.8 kDa 		No 0
ARHGAP26-021
ENSP00000393276
ENST00000443674
H0Y4P9 [Direct mapping]
Rho GTPase-activating protein 26
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0030036 [actin cytoskeleton organization]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 388 aa
42.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.