Expression of SPINK7 in cancer - Summary - The Human Protein Atlas

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SPINK7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPINK7
Gene description	Serine peptidase inhibitor, Kazal type 7 (putative)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (esophagus, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA036294
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036294

GENE INFORMATION
Gene name	SPINK7 (HGNC Symbol)
Synonyms	ECG2, ECRG2
Description	Serine peptidase inhibitor, Kazal type 7 (putative) (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	q32
Chromosome location (bp)	148312419 - 148315922
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145879 (version 83.38)
Entrez gene	84651
UniProt	P58062 (UniProt - Evidence at protein level)
neXtProt	NX_P58062
Antibodypedia	SPINK7 antibodies

PROTEIN BROWSER

SPINK7-001	SPINK7-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPINK7-001 ENSP00000274565 ENST00000274565	P58062 [Direct mapping] Serine protease inhibitor Kazal-type 7 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0010951 [negative regulation of endopeptidase activity] Show all	85 aa 9.2 kDa	Yes	0
SPINK7-005 ENSP00000427887 ENST00000523535	E5RFX6 [Direct mapping] Serine protease inhibitor Kazal-type 7 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	59 aa 6.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.