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ANO7

GENERAL INFORMATION

Gene name

 ANO7

Gene description

 Anoctamin 7

Protein class

 Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Cell line enhanced (BEWO, Hep G2)
HPA (normal tissue):Tissue enhanced (prostate, stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in prostate and stomach glands.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA035730
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035730

GENE INFORMATION

Gene name

 ANO7 (HGNC Symbol)

Synonyms

 IPCA-5, NGEP, PCANAP5, PCANAP5L, TMEM16G

Description

 Anoctamin 7 (HGNC Symbol)

Entrez gene summary

 This prostate-specific gene encodes a cytoplasmic protein, as well as a polytopic membrane protein which may serve as a target in prostate cancer diagnosis and immunotherapy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2011]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241188509 - 241225377

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146205 (version 83.38)

Entrez gene

 50636

UniProt

 Q6IWH7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6IWH7

Antibodypedia

 ANO7 antibodies

PROTEIN BROWSER
ANO7-001
ANO7-002
ANO7-008
ANO7-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANO7-001
ENSP00000274979
ENST00000274979
Q6IWH7 [Direct mapping]
Anoctamin-7
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0006869 [lipid transport]
GO:0016021 [integral component of membrane]
GO:0017128 [phospholipid scramblase activity]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0061589 [calcium activated phosphatidylserine scrambling]
GO:0061590 [calcium activated phosphatidylcholine scrambling]
GO:0061591 [calcium activated galactosylceramide scrambling]
GO:1902476 [chloride transmembrane transport]
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 933 aa
105.5 kDa 		Yes 9
ANO7-002
ENSP00000383985
ENST00000402530
Q6IWH7 [Direct mapping]
Anoctamin-7
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0006869 [lipid transport]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
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 179 aa
19.6 kDa 		Yes 0
ANO7-008
ENSP00000403625
ENST00000451047
H7C220 [Direct mapping]
Anoctamin
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0061588 [calcium activated phospholipid scrambling]
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 186 aa
20.9 kDa 		No 3
ANO7-010
ENSP00000385418
ENST00000402430
Q6IWH7 [Direct mapping]
Anoctamin-7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005622 [intracellular]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006821 [chloride transport]
GO:0006869 [lipid transport]
GO:0016021 [integral component of membrane]
GO:0030054 [cell junction]
GO:0034220 [ion transmembrane transport]
GO:0055085 [transmembrane transport]
Show all
 883 aa
99.8 kDa 		Yes 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.