Expression of TAAR1 in cancer - Summary - The Human Protein Atlas

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TAAR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TAAR1
Gene description	Trace amine associated receptor 1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (fallopian tube, stomach)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA055614
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055614

GENE INFORMATION
Gene name	TAAR1 (HGNC Symbol)
Synonyms	TA1, TAR1, TRAR1
Description	Trace amine associated receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
Chromosome	6
Cytoband	q23.2
Chromosome location (bp)	132644984 - 132646003
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000146399 (version 83.38)
Entrez gene	134864
UniProt	Q96RJ0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96RJ0
Antibodypedia	TAAR1 antibodies

PROTEIN BROWSER

TAAR1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TAAR1-001 ENSP00000275216 ENST00000275216	Q96RJ0 [Direct mapping] Trace amine-associated receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0001594 [trace-amine receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006171 [cAMP biosynthetic process] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007606 [sensory perception of chemical stimulus] GO:0008227 [G-protein coupled amine receptor activity] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	339 aa 39.1 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.