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TAAR1

GENERAL INFORMATION

Gene name

 TAAR1

Gene description

 Trace amine associated receptor 1

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (fallopian tube, stomach)
GTEx:Not detected

Protein evidence

 Evidence at transcript level

Protein expression

 Membranous expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA055614
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (fallopian tube, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected

GENE INFORMATION

Gene name

 TAAR1 (HGNC Symbol)

Synonyms

 TA1, TAR1, TRAR1

Description

 Trace amine associated receptor 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]

Chromosome

 6

Cytoband

 q23.2

Chromosome location (bp)

 132644984 - 132646003

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000146399 (version 83.38)

Entrez gene

 134864

UniProt

 Q96RJ0 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q96RJ0

Antibodypedia

 TAAR1 antibodies

PROTEIN BROWSER
TAAR1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TAAR1-001
ENSP00000275216
ENST00000275216
Q96RJ0 [Direct mapping]
Trace amine-associated receptor 1
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G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0001594 [trace-amine receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006171 [cAMP biosynthetic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007606 [sensory perception of chemical stimulus]
GO:0008227 [G-protein coupled amine receptor activity]
GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
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 339 aa
39.1 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.