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EGFR

GENERAL INFORMATION

Gene name

 EGFR

Gene description

 Epidermal growth factor receptor

Protein class

 Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enriched (A-431)
HPA (normal tissue):Tissue enhanced (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues, most abundant in placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 5 antibodies.
HPA001200 , HPA018530 , CAB000035 , CAB068186 , CAB073534
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA001200
HPA018530
CAB000035
CAB068186
CAB073534

GENE INFORMATION

Gene name

 EGFR (HGNC Symbol)

Synonyms

 ERBB, ERBB1

Description

 Epidermal growth factor receptor (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

 7

Cytoband

 p11.2

Chromosome location (bp)

 55019021 - 55256620

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146648 (version 83.38)

Entrez gene

 1956

UniProt

 P00533 (UniProt - Evidence at protein level)

neXtProt

 NX_P00533

Antibodypedia

 EGFR antibodies

PROTEIN BROWSER
EGFR-001
EGFR-002
EGFR-003
EGFR-004
EGFR-005
EGFR-009
EGFR-201
EGFR-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGFR-001
ENSP00000275493
ENST00000275493
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000902 [cell morphogenesis]
GO:0001503 [ossification]
GO:0001892 [embryonic placenta development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001942 [hair follicle development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007435 [salivary gland morphogenesis]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008544 [epidermis development]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0021795 [cerebral cortex cell migration]
GO:0030122 [AP-2 adaptor complex]
GO:0030139 [endocytic vesicle]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048546 [digestive tract morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060571 [morphogenesis of an epithelial fold]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
 1210 aa
134.3 kDa 		Yes 1
EGFR-002
ENSP00000345973
ENST00000344576
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
 705 aa
77.3 kDa 		Yes 0
EGFR-003
ENSP00000342376
ENST00000342916
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
 628 aa
69.2 kDa 		Yes 0
EGFR-004
ENSP00000415559
ENST00000455089
Q504U8 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006898 [receptor-mediated endocytosis]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 1091 aa
120.7 kDa 		Yes 1
EGFR-005
ENSP00000413843
ENST00000420316
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
 405 aa
44.7 kDa 		Yes 0
EGFR-009
ENSP00000413354
ENST00000450046
C9JYS6 [Direct mapping]
Epidermal growth factor receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
 128 aa
14.7 kDa 		No 0
EGFR-201
ENSP00000410031
ENST00000442591
A0A0B4J1Y5 [Direct mapping]
Epidermal growth factor receptor; Epidermal growth factor receptor (Erythroblastic leukemia viral (V-erb-b) oncogene homolog, avian), isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 657 aa
72.4 kDa 		Yes 0
EGFR-202
ENSP00000395243
ENST00000454757
E9PFD7 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
 1165 aa
129.2 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.