We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
EGFR
  • premium

    TISSUE

  • premium

    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

EGFR

Gene description

Epidermal growth factor receptor

Protein class

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
RAS pathway related proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in several tissues, most abundant in placenta.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 5 antibodies.
HPA001200 , HPA018530 , CAB000035 , CAB068186 , CAB073534
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

EGFR (HGNC Symbol)

Synonyms

ERBB, ERBB1

Description

Epidermal growth factor receptor (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

7

Cytoband

p11.2

Chromosome location (bp)

55019021 - 55256620

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146648 (version 83.38)

Entrez gene

1956

UniProt

P00533 (UniProt - Evidence at protein level)

neXtProt

NX_P00533

Antibodypedia

EGFR antibodies

PROTEIN BROWSER

EGFR-001
EGFR-002
EGFR-003
EGFR-004
EGFR-005
EGFR-009
EGFR-201
EGFR-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EGFR-001
ENSP00000275493
ENST00000275493
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000902 [cell morphogenesis]
GO:0001503 [ossification]
GO:0001892 [embryonic placenta development]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001942 [hair follicle development]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004672 [protein kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004871 [signal transducer activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007435 [salivary gland morphogenesis]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008544 [epidermis development]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016301 [kinase activity]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0021795 [cerebral cortex cell migration]
GO:0030122 [AP-2 adaptor complex]
GO:0030139 [endocytic vesicle]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048546 [digestive tract morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0060571 [morphogenesis of an epithelial fold]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071230 [cellular response to amino acid stimulus]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
1210 aa
134.3 kDa
Yes 1
EGFR-002
ENSP00000345973
ENST00000344576
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
705 aa
77.3 kDa
Yes 0
EGFR-003
ENSP00000342376
ENST00000342916
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
628 aa
69.2 kDa
Yes 0
EGFR-004
ENSP00000415559
ENST00000455089
Q504U8 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0006898 [receptor-mediated endocytosis]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
1091 aa
120.7 kDa
Yes 1
EGFR-005
ENSP00000413843
ENST00000420316
P00533 [Direct mapping]
Epidermal growth factor receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Disease related genes
FDA approved drug targets
   Biotech drugs
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001503 [ossification]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005006 [epidermal growth factor-activated receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007202 [activation of phospholipase C activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0007611 [learning or memory]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0009986 [cell surface]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019903 [protein phosphatase binding]
GO:0030122 [AP-2 adaptor complex]
GO:0030235 [nitric-oxide synthase regulator activity]
GO:0030335 [positive regulation of cell migration]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle]
GO:0031901 [early endosome membrane]
GO:0031965 [nuclear membrane]
GO:0035413 [positive regulation of catenin import into nucleus]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042327 [positive regulation of phosphorylation]
GO:0042802 [identical protein binding]
GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling]
GO:0043066 [negative regulation of apoptotic process]
GO:0043235 [receptor complex]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045429 [positive regulation of nitric oxide biosynthetic process]
GO:0045739 [positive regulation of DNA repair]
GO:0045740 [positive regulation of DNA replication]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050730 [regulation of peptidyl-tyrosine phosphorylation]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0051015 [actin filament binding]
GO:0051205 [protein insertion into membrane]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070141 [response to UV-A]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070435 [Shc-EGFR complex]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0097489 [multivesicular body, internal vesicle lumen]
Show all
405 aa
44.7 kDa
Yes 0
EGFR-009
ENSP00000413354
ENST00000450046
C9JYS6 [Direct mapping]
Epidermal growth factor receptor
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
128 aa
14.7 kDa
No 0
EGFR-201
ENSP00000410031
ENST00000442591
A0A0B4J1Y5 [Direct mapping]
Epidermal growth factor receptor; Epidermal growth factor receptor (Erythroblastic leukemia viral (V-erb-b) oncogene homolog, avian), isoform CRA_b
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
657 aa
72.4 kDa
Yes 0
EGFR-202
ENSP00000395243
ENST00000454757
E9PFD7 [Direct mapping]
Receptor protein-tyrosine kinase
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
RAS pathway related proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Amplifications
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0004716 [receptor signaling protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
Show all
1165 aa
129.2 kDa
Yes 1

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.