We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001503 [ossification] GO:0001934 [positive regulation of protein phosphorylation] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005006 [epidermal growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007611 [learning or memory] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030122 [AP-2 adaptor complex] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030335 [positive regulation of cell migration] GO:0031625 [ubiquitin protein ligase binding] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0035413 [positive regulation of catenin import into nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042327 [positive regulation of phosphorylation] GO:0042802 [identical protein binding] GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045740 [positive regulation of DNA replication] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051015 [actin filament binding] GO:0051205 [protein insertion into membrane] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070141 [response to UV-A] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070435 [Shc-EGFR complex] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0097489 [multivesicular body, internal vesicle lumen]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001503 [ossification] GO:0001934 [positive regulation of protein phosphorylation] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005006 [epidermal growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007611 [learning or memory] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030122 [AP-2 adaptor complex] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030335 [positive regulation of cell migration] GO:0031625 [ubiquitin protein ligase binding] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0035413 [positive regulation of catenin import into nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042327 [positive regulation of phosphorylation] GO:0042802 [identical protein binding] GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045740 [positive regulation of DNA replication] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051015 [actin filament binding] GO:0051205 [protein insertion into membrane] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070141 [response to UV-A] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070435 [Shc-EGFR complex] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0097489 [multivesicular body, internal vesicle lumen]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Disease related genes FDA approved drug targets Biotech drugs Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0001503 [ossification] GO:0001934 [positive regulation of protein phosphorylation] GO:0003682 [chromatin binding] GO:0003690 [double-stranded DNA binding] GO:0004709 [MAP kinase kinase kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004714 [transmembrane receptor protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005006 [epidermal growth factor-activated receptor activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007165 [signal transduction] GO:0007166 [cell surface receptor signaling pathway] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0007611 [learning or memory] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0019903 [protein phosphatase binding] GO:0030122 [AP-2 adaptor complex] GO:0030235 [nitric-oxide synthase regulator activity] GO:0030335 [positive regulation of cell migration] GO:0031625 [ubiquitin protein ligase binding] GO:0031659 [positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle] GO:0031901 [early endosome membrane] GO:0031965 [nuclear membrane] GO:0035413 [positive regulation of catenin import into nucleus] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] GO:0042177 [negative regulation of protein catabolic process] GO:0042327 [positive regulation of phosphorylation] GO:0042802 [identical protein binding] GO:0043006 [activation of phospholipase A2 activity by calcium-mediated signaling] GO:0043066 [negative regulation of apoptotic process] GO:0043235 [receptor complex] GO:0043406 [positive regulation of MAP kinase activity] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045429 [positive regulation of nitric oxide biosynthetic process] GO:0045739 [positive regulation of DNA repair] GO:0045740 [positive regulation of DNA replication] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046777 [protein autophosphorylation] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0050679 [positive regulation of epithelial cell proliferation] GO:0050730 [regulation of peptidyl-tyrosine phosphorylation] GO:0050999 [regulation of nitric-oxide synthase activity] GO:0051015 [actin filament binding] GO:0051205 [protein insertion into membrane] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070141 [response to UV-A] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0070435 [Shc-EGFR complex] GO:0071364 [cellular response to epidermal growth factor stimulus] GO:0071392 [cellular response to estradiol stimulus] GO:0097489 [multivesicular body, internal vesicle lumen]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations COSMIC Germline Mutations Protein evidence (Ezkurdia et al 2014)