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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDCA5
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDCA5

Gene description

Cell division cycle associated 5

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (bone marrow, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including nuclear expression in lymphoid and gastrointestinal tissue.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
HPA023691
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), pancreatic cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA023691

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of cancer tissues showed weak to moderate nuclear immunoreactivity. Seminomas, lymphomas and squamous cell carcinomas showed strong staining. Several renal, liver, lung and stomach cancers were negative.

GENE INFORMATION

Gene name

CDCA5

Synonyms

Description

Cell division cycle associated 5 (HGNC Symbol)

Entrez gene summary

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

65066300 - 65084164

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146670 (version 83.38)

Entrez gene

113130

UniProt

Q96FF9 (UniProt - Evidence at protein level)

neXtProt

NX_Q96FF9

Antibodypedia

CDCA5 antibodies

PROTEIN BROWSER

CDCA5-001
CDCA5-005
CDCA5-007
CDCA5-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDCA5-001
ENSP00000275517
ENST00000275517
Q96FF9 [Direct mapping]
Sororin
A0A024R5D6 [Target identity:100%; Query identity:100%]
Cell division cycle associated 5, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006302 [double-strand break repair]
GO:0007064 [mitotic sister chromatid cohesion]
GO:0007067 [mitotic nuclear division]
GO:0007076 [mitotic chromosome condensation]
GO:0007080 [mitotic metaphase plate congression]
GO:0008278 [cohesin complex]
GO:0031536 [positive regulation of exit from mitosis]
GO:0051301 [cell division]
GO:0071922 [regulation of cohesin localization to chromatin]
GO:1901989 [positive regulation of cell cycle phase transition]
Show all
252 aa
27.6 kDa
No 0
CDCA5-005
ENSP00000385711
ENST00000404147
B5MBX0 [Direct mapping]
Sororin
Show all
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005886 [plasma membrane]
Show all
307 aa
33.7 kDa
No 0
CDCA5-007
ENSP00000432183
ENST00000529290
H0YCR8 [Direct mapping]
Sororin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
254 aa
28.2 kDa
No 0
CDCA5-009
ENSP00000432342
ENST00000525464
H0YCT9 [Direct mapping]
Sororin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
224 aa
25.4 kDa
No 0

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