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IGFBP3

GENERAL INFORMATION

Gene name

 IGFBP3

Gene description

 Insulin-like growth factor binding protein 3

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (placenta)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IGFBP3 (HGNC Symbol)

Synonyms

 BP-53, IBP3

Description

 Insulin-like growth factor binding protein 3 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 p12.3

Chromosome location (bp)

 45912245 - 45921874

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146674 (version 83.38)

Entrez gene

 3486

UniProt

 P17936 (UniProt - Evidence at protein level)

neXtProt

 NX_P17936

Antibodypedia

 IGFBP3 antibodies

PROTEIN BROWSER
IGFBP3-001
IGFBP3-008
IGFBP3-014
IGFBP3-018
IGFBP3-019
IGFBP3-020
IGFBP3-201
IGFBP3-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IGFBP3-001
ENSP00000275521
ENST00000275521
P17936 [Direct mapping]
Insulin-like growth factor-binding protein 3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001968 [fibronectin binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009968 [negative regulation of signal transduction]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0046872 [metal ion binding]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0070062 [extracellular exosome]
Show all
 291 aa
31.7 kDa 		Yes 0
IGFBP3-008
ENSP00000370476
ENST00000381086
B3KWK7 [Direct mapping]
Insulin-like growth factor binding protein 3, isoform CRA_b; Insulin-like growth factor-binding protein 3; cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0005576 [extracellular region]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 194 aa
21.8 kDa 		No 0
IGFBP3-014
ENSP00000389668
ENST00000448817
C9JMX4 [Direct mapping]
Insulin-like growth factor-binding protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0005576 [extracellular region]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 132 aa
14.9 kDa 		No 0
IGFBP3-018
ENSP00000390298
ENST00000428530
H0Y485 [Direct mapping]
Insulin-like growth factor-binding protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0005576 [extracellular region]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 143 aa
16.4 kDa 		No 0
IGFBP3-019
ENSP00000399116
ENST00000417621
H0Y5K2 [Direct mapping]
Insulin-like growth factor-binding protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0005576 [extracellular region]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 153 aa
17.5 kDa 		No 0
IGFBP3-020
ENSP00000370473
ENST00000381083
P17936 [Direct mapping]
Insulin-like growth factor-binding protein 3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001649 [osteoblast differentiation]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001968 [fibronectin binding]
GO:0005515 [protein binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0008160 [protein tyrosine phosphatase activator activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009968 [negative regulation of signal transduction]
GO:0010906 [regulation of glucose metabolic process]
GO:0014912 [negative regulation of smooth muscle cell migration]
GO:0016942 [insulin-like growth factor binding protein complex]
GO:0031994 [insulin-like growth factor I binding]
GO:0031995 [insulin-like growth factor II binding]
GO:0040008 [regulation of growth]
GO:0042567 [insulin-like growth factor ternary complex]
GO:0043065 [positive regulation of apoptotic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway]
GO:0044267 [cellular protein metabolic process]
GO:0044342 [type B pancreatic cell proliferation]
GO:0045663 [positive regulation of myoblast differentiation]
GO:0046872 [metal ion binding]
GO:0048662 [negative regulation of smooth muscle cell proliferation]
GO:0070062 [extracellular exosome]
Show all
 297 aa
32.2 kDa 		Yes 0
IGFBP3-201
ENSP00000477772
ENST00000613132
A6XND0 [Direct mapping]
Insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001968 [fibronectin binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 270 aa
29.7 kDa 		Yes 0
IGFBP3-202
ENSP00000480717
ENST00000615754
A6XND1 [Direct mapping]
Insulin-like growth factor binding protein 3 isoform b; Insulin-like growth factor-binding protein 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001558 [regulation of cell growth]
GO:0001968 [fibronectin binding]
GO:0005520 [insulin-like growth factor binding]
GO:0005576 [extracellular region]
GO:0031995 [insulin-like growth factor II binding]
GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway]
Show all
 263 aa
29 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.