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MDH2

GENERAL INFORMATION

Gene name

 MDH2

Gene description

 Malate dehydrogenase 2, NAD (mitochondrial)

Protein class

 Citric acid cycle related proteins
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 4 antibodies.
HPA019714 , HPA019716 , HPA019848 , HPA026720
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019714
HPA019716
HPA019848
HPA026720

GENE INFORMATION

Gene name

 MDH2

Synonyms

Description

 Malate dehydrogenase 2, NAD (mitochondrial) (HGNC Symbol)

Entrez gene summary

 Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 76048051 - 76067508

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146701 (version 83.38)

Entrez gene

 4191

UniProt

 P40926 (UniProt - Evidence at protein level)

neXtProt

 NX_P40926

Antibodypedia

 MDH2 antibodies

PROTEIN BROWSER
MDH2-001
MDH2-002
MDH2-003
MDH2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MDH2-001
ENSP00000327070
ENST00000315758
P40926 [Direct mapping]
Malate dehydrogenase, mitochondrial
A0A024R4K3 [Target identity:100%; Query identity:100%]
Malate dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006099 [tricarboxylic acid cycle]
GO:0006107 [oxaloacetate metabolic process]
GO:0006108 [malate metabolic process]
GO:0006475 [internal protein amino acid acetylation]
GO:0006734 [NADH metabolic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016615 [malate dehydrogenase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0030060 [L-malate dehydrogenase activity]
GO:0043209 [myelin sheath]
GO:0043621 [protein self-association]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046554 [malate dehydrogenase (NADP+) activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 338 aa
35.5 kDa 		No 0
MDH2-002
ENSP00000408649
ENST00000432020
P40926 [Direct mapping]
Malate dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006099 [tricarboxylic acid cycle]
GO:0006108 [malate metabolic process]
GO:0006475 [internal protein amino acid acetylation]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0030060 [L-malate dehydrogenase activity]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 296 aa
30.9 kDa 		No 0
MDH2-003
ENSP00000475583
ENST00000461263
U3KQ63 [Direct mapping]
Malate dehydrogenase, mitochondrial
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
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 28 aa
2.9 kDa 		No 0
MDH2-004
ENSP00000416929
ENST00000443006
G3XAL0 [Direct mapping]
Malate dehydrogenase
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Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006099 [tricarboxylic acid cycle]
GO:0006108 [malate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016615 [malate dehydrogenase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0030060 [L-malate dehydrogenase activity]
GO:0055114 [oxidation-reduction process]
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 231 aa
24.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.