We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Cancer tissues showed moderate immunoreactivity. Several cases of colorectal cancers showed strong cytoplasmic and membranous positivity. Gliomas and lymphomas were weakly stained or negative.
GENE INFORMATION
Gene name
EPHA1 (HGNC Symbol)
Synonyms
EPH, EPHT, EPHT1
Description
EPH receptor A1 (HGNC Symbol)
Entrez gene summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]