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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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EPHA1
  • TISSUE

  • CELL

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

EPHA1

Gene description

EPH receptor A1

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (parathyroid gland)
GTEx:Tissue enhanced (esophagus)
FANTOM5:Tissue enhanced (esophagus)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and membranous expression in most tissues, including parathyroid gland.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
CAB026144
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Parathyroid gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (esophagus)

GENE INFORMATION

Gene name

EPHA1 (HGNC Symbol)

Synonyms

EPH, EPHT, EPHT1

Description

EPH receptor A1 (HGNC Symbol)

Entrez gene summary

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

Chromosome location (bp)

143390289 - 143408892

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000146904 (version 83.38)

Entrez gene

2041

UniProt

P21709 (UniProt - Evidence at protein level)

neXtProt

NX_P21709

Antibodypedia

EPHA1 antibodies

PROTEIN BROWSER

EPHA1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EPHA1-001
ENSP00000275815
ENST00000275815
P21709 [Direct mapping]
Ephrin type-A receptor 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005003 [ephrin receptor activity]
GO:0005005 [transmembrane-ephrin receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007411 [axon guidance]
GO:0008284 [positive regulation of cell proliferation]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0030335 [positive regulation of cell migration]
GO:0030336 [negative regulation of cell migration]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0035019 [somatic stem cell population maintenance]
GO:0043087 [regulation of GTPase activity]
GO:0045766 [positive regulation of angiogenesis]
GO:0046777 [protein autophosphorylation]
GO:0048013 [ephrin receptor signaling pathway]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0090630 [activation of GTPase activity]
Show all
976 aa
108.1 kDa
Yes 2

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