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NLGN4X

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GENERAL INFORMATION

Gene name

 NLGN4X

Gene description

 Neuroligin 4, X-linked

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (AF22, NTERA-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (AF22, NTERA-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NLGN4X (HGNC Symbol)

Synonyms

 HLNX, KIAA1260, NLGN, NLGN4

Description

 Neuroligin 4, X-linked (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

Chromosome location (bp)

 5840637 - 6228863

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146938 (version 83.38)

Entrez gene

 57502

UniProt

 Q8N0W4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N0W4

Antibodypedia

 NLGN4X antibodies

PROTEIN BROWSER
NLGN4X-001
NLGN4X-003
NLGN4X-004
NLGN4X-201
NLGN4X-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLGN4X-001
ENSP00000275857
ENST00000275857
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-003
ENSP00000370482
ENST00000381092
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-004
ENSP00000370485
ENST00000381095
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-201
ENSP00000370483
ENST00000381093
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-202
ENSP00000439203
ENST00000538097
A0A0A0MTH0 [Direct mapping]
Neuroligin-4, X-linked
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0042043 [neurexin family protein binding]
Show all
 817 aa
91.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.