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NLGN4X

GENERAL INFORMATION

Gene name

 NLGN4X

Gene description

 Neuroligin 4, X-linked

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Group enriched (AF22, NTERA-2)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic positivity in CNS and peripheral ganglia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA001651
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA001651

GENE INFORMATION

Gene name

 NLGN4X (HGNC Symbol)

Synonyms

 HLNX, KIAA1260, NLGN, NLGN4

Description

 Neuroligin 4, X-linked (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

 X

Cytoband

Chromosome location (bp)

 5840637 - 6228863

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000146938 (version 83.38)

Entrez gene

 57502

UniProt

 Q8N0W4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N0W4

Antibodypedia

 NLGN4X antibodies

PROTEIN BROWSER
NLGN4X-001
NLGN4X-003
NLGN4X-004
NLGN4X-201
NLGN4X-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NLGN4X-001
ENSP00000275857
ENST00000275857
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-003
ENSP00000370482
ENST00000381092
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-004
ENSP00000370485
ENST00000381095
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-201
ENSP00000370483
ENST00000381093
Q8N0W4 [Direct mapping]
Neuroligin-4, X-linked
A0A024RBV0 [Target identity:100%; Query identity:100%]
Neuroligin 4, X-linked, isoform CRA_a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003360 [brainstem development]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007158 [neuron cell-cell adhesion]
GO:0007612 [learning]
GO:0009986 [cell surface]
GO:0014069 [postsynaptic density]
GO:0016021 [integral component of membrane]
GO:0021549 [cerebellum development]
GO:0030054 [cell junction]
GO:0030182 [neuron differentiation]
GO:0030425 [dendrite]
GO:0030534 [adult behavior]
GO:0031404 [chloride ion binding]
GO:0035176 [social behavior]
GO:0035265 [organ growth]
GO:0042043 [neurexin family protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0045216 [cell-cell junction organization]
GO:0048488 [synaptic vesicle endocytosis]
GO:0050804 [modulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050839 [cell adhesion molecule binding]
GO:0060076 [excitatory synapse]
GO:0071625 [vocalization behavior]
GO:0090394 [negative regulation of excitatory postsynaptic potential]
GO:0097104 [postsynaptic membrane assembly]
GO:0097105 [presynaptic membrane assembly]
GO:0097110 [scaffold protein binding]
Show all
 816 aa
91.9 kDa 		Yes 1
NLGN4X-202
ENSP00000439203
ENST00000538097
A0A0A0MTH0 [Direct mapping]
Neuroligin-4, X-linked
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
GO:0042043 [neurexin family protein binding]
Show all
 817 aa
91.9 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.