Tissue expression of IGSF1 - Summary - The Human Protein Atlas

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IGSF1

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IGSF1
Gene description	Immunoglobulin superfamily, member 1
Protein class	Disease related genes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Tissue enriched (pituitary gland)
FANTOM5:	Tissue enriched (pituitary gland)

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in cells of the anterior pituitary gland.

DATA RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Antibody staining mainly consistent with external characterization data and GTEx RNA expression data.
Reliability score	Supported based on 1 antibody. HPA035582
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Pituitary gland

N/A

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Pituitary gland

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (pituitary gland)

GENE INFORMATION
Gene name	IGSF1 (HGNC Symbol)
Synonyms	IGCD1, IGDC1, INHBP, KIAA0364, MGC75490, PGSF2
Description	Immunoglobulin superfamily, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the immunoglobulin-like domain-containing superfamily. Proteins in this superfamily contain varying numbers of immunoglobulin-like domains and are thought to participate in the regulation of interactions between cells. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband
Chromosome location (bp)	131273506 - 131578899
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147255 (version 83.38)
Entrez gene	3547
UniProt	Q8N6C5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N6C5
Antibodypedia	IGSF1 antibodies

PROTEIN BROWSER

IGSF1-001	IGSF1-002	IGSF1-003	IGSF1-004	IGSF1-007	IGSF1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGSF1-001 ENSP00000359941 ENST00000370904	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1327 aa 148 kDa	Yes	3
IGSF1-002 ENSP00000359947 ENST00000370910	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1327 aa 148 kDa	Yes	3
IGSF1-003 ENSP00000355010 ENST00000361420	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1336 aa 148.9 kDa	Yes	3
IGSF1-004 ENSP00000359938 ENST00000370901	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	242 aa 27.2 kDa	Yes	0
IGSF1-007 ENSP00000359937 ENST00000370900	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	242 aa 27.2 kDa	Yes	0
IGSF1-201 ENSP00000359940 ENST00000370903	Q8N6C5 [Direct mapping] Immunoglobulin superfamily member 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006355 [regulation of transcription, DNA-templated] GO:0007165 [signal transduction] GO:0015026 [coreceptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034711 [inhibin binding] Show all	1341 aa 149.4 kDa	Yes	3

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.