Expression of FATE1 in cancer - Summary - The Human Protein Atlas

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FATE1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FATE1
Gene description	Fetal and adult testis expressed 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (renal cancer, testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression of cells in seminiferous ducts in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA034604
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (renal cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034604

GENE INFORMATION
Gene name	FATE1 (HGNC Symbol)
Synonyms	CT43, FATE
Description	Fetal and adult testis expressed 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	151716035 - 151723194
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147378 (version 83.38)
Entrez gene	89885
UniProt	Q969F0 (UniProt - Evidence at protein level)
neXtProt	NX_Q969F0
Antibodypedia	FATE1 antibodies

PROTEIN BROWSER

FATE1-001	FATE1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FATE1-001 ENSP00000359375 ENST00000370350	Q969F0 [Direct mapping] Fetal and adult testis-expressed transcript protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] Show all	183 aa 20.7 kDa	No	1
FATE1-003 ENSP00000400493 ENST00000417321	H7C1I5 [Direct mapping] Fetal and adult testis-expressed transcript protein Show all	Predicted intracellular proteins Show all		80 aa 8.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.