Expression of MAGEA4 in cancer - Summary - The Human Protein Atlas

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MAGEA4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAGEA4
Gene description	Melanoma antigen family A4
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A-431, AN3-CA, HMC-1, U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in seminiferous ducts of testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Pending retesting.
Reliability score	Supported based on 2 antibodies. HPA021942 , CAB040535
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA021942	CAB040535

GENE INFORMATION
Gene name	MAGEA4 (HGNC Symbol)
Synonyms	CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B, MGC21336
Description	Melanoma antigen family A4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	151912509 - 151925170
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147381 (version 83.38)
Entrez gene	4103
UniProt	P43358 (UniProt - Evidence at protein level)
neXtProt	NX_P43358
Antibodypedia	MAGEA4 antibodies

PROTEIN BROWSER

MAGEA4-001	MAGEA4-002	MAGEA4-003	MAGEA4-004	MAGEA4-005	MAGEA4-006	MAGEA4-007	MAGEA4-008	MAGEA4-009	MAGEA4-010	MAGEA4-011	MAGEA4-201	MAGEA4-202	MAGEA4-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGEA4-001 ENSP00000391904 ENST00000448295	C9J9C2 [Direct mapping] Melanoma-associated antigen 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		217 aa 23.3 kDa	No	1
MAGEA4-002 ENSP00000390096 ENST00000431971	C9JIR1 [Direct mapping] Melanoma-associated antigen 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 26 kDa	No	0
MAGEA4-003 ENSP00000394149 ENST00000430273	C9JIR1 [Direct mapping] Melanoma-associated antigen 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 26 kDa	No	0
MAGEA4-004 ENSP00000394073 ENST00000416020	C9JK50 [Direct mapping] Melanoma-associated antigen 4 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		230 aa 24.7 kDa	No	0
MAGEA4-005 ENSP00000402624 ENST00000441865	C9JIR1 [Direct mapping] Melanoma-associated antigen 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 26 kDa	No	0
MAGEA4-006 ENSP00000400900 ENST00000425182	C9J9C2 [Direct mapping] Melanoma-associated antigen 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		217 aa 23.3 kDa	No	1
MAGEA4-007 ENSP00000402186 ENST00000457310	C9JIR1 [Direct mapping] Melanoma-associated antigen 4 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		241 aa 26 kDa	No	0
MAGEA4-008 ENSP00000359365 ENST00000370340	P43358 [Direct mapping] Melanoma-associated antigen 4 A0A024RC12 [Target identity:100%; Query identity:100%] Melanoma antigen family A, 4, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	317 aa 34.9 kDa	No	0
MAGEA4-009 ENSP00000359360 ENST00000370335	P43358 [Direct mapping] Melanoma-associated antigen 4 A0A024RC12 [Target identity:100%; Query identity:100%] Melanoma antigen family A, 4, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	317 aa 34.9 kDa	No	0
MAGEA4-010 ENSP00000353379 ENST00000360243	P43358 [Direct mapping] Melanoma-associated antigen 4 A0A024RC12 [Target identity:100%; Query identity:100%] Melanoma antigen family A, 4, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	317 aa 34.9 kDa	No	0
MAGEA4-011 ENSP00000387777 ENST00000431963	C9JZJ5 [Direct mapping] Melanoma-associated antigen 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		172 aa 18.6 kDa	No	0
MAGEA4-201 ENSP00000276344 ENST00000276344	P43358 [Direct mapping] Melanoma-associated antigen 4 A0A024RC12 [Target identity:100%; Query identity:100%] Melanoma antigen family A, 4, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	317 aa 34.9 kDa	No	0
MAGEA4-202 ENSP00000377497 ENST00000393920	P43358 [Direct mapping] Melanoma-associated antigen 4 A0A024RC12 [Target identity:100%; Query identity:100%] Melanoma antigen family A, 4, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	317 aa 34.9 kDa	No	0
MAGEA4-203 ENSP00000377498 ENST00000393921	P43358 [Direct mapping] Melanoma-associated antigen 4 A0A024RC12 [Target identity:100%; Query identity:100%] Melanoma antigen family A, 4, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	317 aa 34.9 kDa	No	0

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