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Gene name

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Chromosome

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In atlas

Reliability

Reliability

Reliability

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Method

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Method

Validation

Method

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Searches

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Cell line

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Cancer

Specificity

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Detectable

Cell line

Detectable

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MAGEA4
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

MAGEA4

Gene description

Melanoma antigen family A4

Protein class

Cancer-related genes
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

14
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enriched (testis)
GTEx:Tissue enriched (testis)
FANTOM5:Group enriched (placenta, testis)

Protein evidence

Evidence at protein level

Protein expression

Selective expression in seminiferous ducts of testis.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data. Pending retesting.

Reliability score

Supported based on 2 antibodies.
HPA021942 , CAB040535
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (placenta, testis)

GENE INFORMATION

Gene name

MAGEA4 (HGNC Symbol)

Synonyms

CT1.4, MAGE-41, MAGE-X2, MAGE4, MAGE4A, MAGE4B, MGC21336

Description

Melanoma antigen family A4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q28

Chromosome location (bp)

151912509 - 151925170

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000147381 (version 83.38)

Entrez gene

4103

UniProt

P43358 (UniProt - Evidence at protein level)

neXtProt

NX_P43358

Antibodypedia

MAGEA4 antibodies

PROTEIN BROWSER

«
MAGEA4-001
MAGEA4-002
MAGEA4-003
MAGEA4-004
MAGEA4-005
MAGEA4-006
MAGEA4-007
MAGEA4-008
MAGEA4-009
MAGEA4-010
MAGEA4-011
MAGEA4-201
MAGEA4-202
MAGEA4-203
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAGEA4-001
ENSP00000391904
ENST00000448295
C9J9C2 [Direct mapping]
Melanoma-associated antigen 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
217 aa
23.3 kDa
No 1
MAGEA4-002
ENSP00000390096
ENST00000431971
C9JIR1 [Direct mapping]
Melanoma-associated antigen 4
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
241 aa
26 kDa
No 0
MAGEA4-003
ENSP00000394149
ENST00000430273
C9JIR1 [Direct mapping]
Melanoma-associated antigen 4
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
241 aa
26 kDa
No 0
MAGEA4-004
ENSP00000394073
ENST00000416020
C9JK50 [Direct mapping]
Melanoma-associated antigen 4
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
230 aa
24.7 kDa
No 0
MAGEA4-005
ENSP00000402624
ENST00000441865
C9JIR1 [Direct mapping]
Melanoma-associated antigen 4
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
241 aa
26 kDa
No 0
MAGEA4-006
ENSP00000400900
ENST00000425182
C9J9C2 [Direct mapping]
Melanoma-associated antigen 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
217 aa
23.3 kDa
No 1
MAGEA4-007
ENSP00000402186
ENST00000457310
C9JIR1 [Direct mapping]
Melanoma-associated antigen 4
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
241 aa
26 kDa
No 0
MAGEA4-008
ENSP00000359365
ENST00000370340
P43358 [Direct mapping]
Melanoma-associated antigen 4
A0A024RC12 [Target identity:100%; Query identity:100%]
Melanoma antigen family A, 4, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
Show all
317 aa
34.9 kDa
No 0
MAGEA4-009
ENSP00000359360
ENST00000370335
P43358 [Direct mapping]
Melanoma-associated antigen 4
A0A024RC12 [Target identity:100%; Query identity:100%]
Melanoma antigen family A, 4, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
Show all
317 aa
34.9 kDa
No 0
MAGEA4-010
ENSP00000353379
ENST00000360243
P43358 [Direct mapping]
Melanoma-associated antigen 4
A0A024RC12 [Target identity:100%; Query identity:100%]
Melanoma antigen family A, 4, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
Show all
317 aa
34.9 kDa
No 0
MAGEA4-011
ENSP00000387777
ENST00000431963
C9JZJ5 [Direct mapping]
Melanoma-associated antigen 4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
172 aa
18.6 kDa
No 0
MAGEA4-201
ENSP00000276344
ENST00000276344
P43358 [Direct mapping]
Melanoma-associated antigen 4
A0A024RC12 [Target identity:100%; Query identity:100%]
Melanoma antigen family A, 4, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
Show all
317 aa
34.9 kDa
No 0
MAGEA4-202
ENSP00000377497
ENST00000393920
P43358 [Direct mapping]
Melanoma-associated antigen 4
A0A024RC12 [Target identity:100%; Query identity:100%]
Melanoma antigen family A, 4, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
Show all
317 aa
34.9 kDa
No 0
MAGEA4-203
ENSP00000377498
ENST00000393921
P43358 [Direct mapping]
Melanoma-associated antigen 4
A0A024RC12 [Target identity:100%; Query identity:100%]
Melanoma antigen family A, 4, isoform CRA_a
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0008150 [biological_process]
Show all
317 aa
34.9 kDa
No 0

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The Human Protein Atlas project is funded
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