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BIN3

GENERAL INFORMATION

Gene name

 BIN3

Gene description

 Bridging integrator 3

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA023769
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023769

GENE INFORMATION

Gene name

 BIN3

Synonyms

Description

 Bridging integrator 3 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a member of the BAR domain protein family. The encoded protein is comprised solely of a BAR domain which is predicted to form coiled-coil structures and proposed to mediate dimerization, sense and induce membrane curvature, and bind small GTPases. BAR domain proteins have been implicated in endocytosis, intracellular transport, and a diverse set of other processes. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 p21.3

Chromosome location (bp)

 22620418 - 22669148

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147439 (version 83.38)

Entrez gene

 55909

UniProt

 Q9NQY0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQY0

Antibodypedia

 BIN3 antibodies

PROTEIN BROWSER
BIN3-001
BIN3-002
BIN3-003
BIN3-007
BIN3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BIN3-001
ENSP00000276416
ENST00000276416
Q9NQY0 [Direct mapping]
Bridging integrator 3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000910 [cytokinesis]
GO:0000917 [barrier septum assembly]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005884 [actin filament]
GO:0007015 [actin filament organization]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008104 [protein localization]
GO:0009826 [unidimensional cell growth]
GO:0010591 [regulation of lamellipodium assembly]
GO:0014839 [myoblast migration involved in skeletal muscle regeneration]
GO:0043403 [skeletal muscle tissue regeneration]
GO:0048741 [skeletal muscle fiber development]
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 253 aa
29.7 kDa 		No 0
BIN3-002
ENSP00000430423
ENST00000519513
Q9NQY0 [Direct mapping]
Bridging integrator 3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000910 [cytokinesis]
GO:0000917 [barrier septum assembly]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007015 [actin filament organization]
GO:0008093 [cytoskeletal adaptor activity]
GO:0008104 [protein localization]
GO:0009826 [unidimensional cell growth]
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 199 aa
23.2 kDa 		No 0
BIN3-003
ENSP00000382859
ENST00000399977
H7BYV6 [Direct mapping]
Bridging integrator 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
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 205 aa
23.9 kDa 		No 0
BIN3-007
ENSP00000428768
ENST00000522268
E5RGB5 [Direct mapping]
Bridging integrator 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 27 aa
3.1 kDa 		No 0
BIN3-011
ENSP00000429660
ENST00000520292
E5RHU4 [Direct mapping]
Bridging integrator 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 149 aa
17.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.