Expression of PLPP5 in cancer - Summary - The Human Protein Atlas

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PLPP5

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	PLPP5
Gene description	Phospholipid phosphatase 5
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), endometrial cancer (favourable), ovarian cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Ovarian cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	PLPP5 (HGNC Symbol)
Synonyms	DPPL1, HTPAP, PPAPDC1B
Description	Phospholipid phosphatase 5 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38263130 - 38269243
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147535 (version 83.38)
Entrez gene	84513
UniProt	Q8NEB5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NEB5
Antibodypedia	PLPP5 antibodies

PROTEIN BROWSER

PLPP5-001	PLPP5-002	PLPP5-003	PLPP5-005	PLPP5-006	PLPP5-007	PLPP5-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLPP5-001 ENSP00000392553 ENST00000424479	Q8NEB5 [Direct mapping] Phosphatidate phosphatase PPAPDC1B Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	264 aa 29.5 kDa	No	6
PLPP5-002 ENSP00000390622 ENST00000422581	Q8NEB5 [Direct mapping] Phosphatidate phosphatase PPAPDC1B Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	216 aa 24.1 kDa	No	5
PLPP5-003 ENSP00000414522 ENST00000419686	Q8NEB5 [Direct mapping] Phosphatidate phosphatase PPAPDC1B Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	176 aa 19.7 kDa	No	3
PLPP5-005 ENSP00000434916 ENST00000529359	Q8NEB5 [Direct mapping] Phosphatidate phosphatase PPAPDC1B Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006644 [phospholipid metabolic process] GO:0007165 [signal transduction] GO:0008195 [phosphatidate phosphatase activity] GO:0046839 [phospholipid dephosphorylation] Show all	223 aa 25.2 kDa	No	5
PLPP5-006 ENSP00000431771 ENST00000534339	H0YCK0 [Direct mapping] Phosphatidate phosphatase PPAPDC1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0008195 [phosphatidate phosphatase activity] GO:0016021 [integral component of membrane] GO:0046839 [phospholipid dephosphorylation] Show all	244 aa 27.5 kDa	No	5
PLPP5-007 ENSP00000432122 ENST00000524616	H0YCQ3 [Direct mapping] Phosphatidate phosphatase PPAPDC1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0008195 [phosphatidate phosphatase activity] GO:0016021 [integral component of membrane] GO:0046839 [phospholipid dephosphorylation] Show all	245 aa 27.4 kDa	No	5
PLPP5-015 ENSP00000437248 ENST00000531823	E9PNB1 [Direct mapping] Phosphatidate phosphatase PPAPDC1B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0008195 [phosphatidate phosphatase activity] GO:0016021 [integral component of membrane] GO:0046839 [phospholipid dephosphorylation] Show all	132 aa 14.8 kDa	No	3

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