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TERF1

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GENERAL INFORMATION

Gene name

 TERF1

Gene description

 Telomeric repeat binding factor (NIMA-interacting) 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoli (fibrillar center). In addition localized to the nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoli fibrillar center (supported)

Additional location

 In addition localized to the Nuclear bodies (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA048379
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoli (fibrillar center). In addition localized to the nuclear bodies.

Main location

 Nucleoli fibrillar center (supported)

Additional location

 Nuclear bodies (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA048379 HEK 293 Nucleoli fibrillar center
HPA048379 MCF7 Nucleoli fibrillar center
Nuclear bodies
HPA048379 U-2 OS Nucleoli fibrillar center
Nuclear bodies

GENE INFORMATION

Gene name

 TERF1 (HGNC Symbol)

Synonyms

 PIN2, TRBF1, TRF, TRF1

Description

 Telomeric repeat binding factor (NIMA-interacting) 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q21.11

Chromosome location (bp)

 73008864 - 73048122

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147601 (version 83.38)

Entrez gene

 7013

UniProt

 P54274 (UniProt - Evidence at protein level)

neXtProt

 NX_P54274

Antibodypedia

 TERF1 antibodies

PROTEIN BROWSER
TERF1-001
TERF1-002
TERF1-005
TERF1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TERF1-001
ENSP00000276603
ENST00000276603
P54274 [Direct mapping]
Telomeric repeat-binding factor 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0007004 [telomere maintenance via telomerase]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008017 [microtubule binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008301 [DNA binding, bending]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031627 [telomeric loop formation]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032214 [negative regulation of telomere maintenance via semi-conservative replication]
GO:0042162 [telomeric DNA binding]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0045141 [meiotic telomere clustering]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0051260 [protein homooligomerization]
GO:0051301 [cell division]
GO:0051974 [negative regulation of telomerase activity]
GO:0070187 [telosome]
Show all
 439 aa
50.2 kDa 		No 0
TERF1-002
ENSP00000276602
ENST00000276602
P54274 [Direct mapping]
Telomeric repeat-binding factor 1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000723 [telomere maintenance]
GO:0000781 [chromosome, telomeric region]
GO:0000783 [nuclear telomere cap complex]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0003677 [DNA binding]
GO:0003691 [double-stranded telomeric DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0007004 [telomere maintenance via telomerase]
GO:0007067 [mitotic nuclear division]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008017 [microtubule binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008301 [DNA binding, bending]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031627 [telomeric loop formation]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032214 [negative regulation of telomere maintenance via semi-conservative replication]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0045840 [positive regulation of mitotic nuclear division]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046982 [protein heterodimerization activity]
GO:0051260 [protein homooligomerization]
GO:0051301 [cell division]
GO:0051974 [negative regulation of telomerase activity]
GO:0070187 [telosome]
Show all
 419 aa
48.2 kDa 		No 0
TERF1-005
ENSP00000428838
ENST00000518874
E5RFJ5 [Direct mapping]
Telomeric repeat-binding factor 1
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0031627 [telomeric loop formation]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
Show all
 168 aa
19 kDa 		No 0
TERF1-006
ENSP00000430121
ENST00000517390
E7EWM7 [Direct mapping]
Telomeric repeat-binding factor 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0031627 [telomeric loop formation]
GO:0042162 [telomeric DNA binding]
GO:0042803 [protein homodimerization activity]
Show all
 186 aa
21.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.