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DPYS

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GENERAL INFORMATION

Gene name

 DPYS

Gene description

 Dihydropyrimidinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DPYS (HGNC Symbol)

Synonyms

 DHPase

Description

 Dihydropyrimidinase (HGNC Symbol)

Entrez gene summary

 Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q22.3

Chromosome location (bp)

 104330324 - 104467053

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147647 (version 83.38)

Entrez gene

 1807

UniProt

 Q14117 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14117

Antibodypedia

 DPYS antibodies

PROTEIN BROWSER
DPYS-001
DPYS-005
DPYS-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPYS-001
ENSP00000276651
ENST00000351513
Q14117 [Direct mapping]
Dihydropyrimidinase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002058 [uracil binding]
GO:0002059 [thymine binding]
GO:0004157 [dihydropyrimidinase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006208 [pyrimidine nucleobase catabolic process]
GO:0006210 [thymine catabolic process]
GO:0006212 [uracil catabolic process]
GO:0008270 [zinc ion binding]
GO:0016597 [amino acid binding]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0019482 [beta-alanine metabolic process]
GO:0019860 [uracil metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0051219 [phosphoprotein binding]
GO:0051260 [protein homooligomerization]
GO:0051289 [protein homotetramerization]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 519 aa
56.6 kDa 		No 0
DPYS-005
ENSP00000430246
ENST00000521573
E5RG28 [Direct mapping]
Dihydropyrimidinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 150 aa
16.2 kDa 		No 0
DPYS-007
ENSP00000436654
ENST00000533874
H0YEV7 [Direct mapping]
Dihydropyrimidinase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
Show all
 54 aa
6.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.