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DPYS

GENERAL INFORMATION

Gene name

 DPYS

Gene description

 Dihydropyrimidinase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (liver cancer, renal cancer)
HPA (cell line):Not detected
HPA (normal tissue):Group enriched (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in liver and kidney.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA024785
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (liver cancer, renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024785

GENE INFORMATION

Gene name

 DPYS (HGNC Symbol)

Synonyms

 DHPase

Description

 Dihydropyrimidinase (HGNC Symbol)

Entrez gene summary

 Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q22.3

Chromosome location (bp)

 104330324 - 104467053

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000147647 (version 83.38)

Entrez gene

 1807

UniProt

 Q14117 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14117

Antibodypedia

 DPYS antibodies

PROTEIN BROWSER
DPYS-001
DPYS-005
DPYS-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DPYS-001
ENSP00000276651
ENST00000351513
Q14117 [Direct mapping]
Dihydropyrimidinase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002058 [uracil binding]
GO:0002059 [thymine binding]
GO:0004157 [dihydropyrimidinase activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006206 [pyrimidine nucleobase metabolic process]
GO:0006208 [pyrimidine nucleobase catabolic process]
GO:0006210 [thymine catabolic process]
GO:0006212 [uracil catabolic process]
GO:0008270 [zinc ion binding]
GO:0016597 [amino acid binding]
GO:0016787 [hydrolase activity]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
GO:0019482 [beta-alanine metabolic process]
GO:0019860 [uracil metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046135 [pyrimidine nucleoside catabolic process]
GO:0051219 [phosphoprotein binding]
GO:0051260 [protein homooligomerization]
GO:0051289 [protein homotetramerization]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 519 aa
56.6 kDa 		No 0
DPYS-005
ENSP00000430246
ENST00000521573
E5RG28 [Direct mapping]
Dihydropyrimidinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
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 150 aa
16.2 kDa 		No 0
DPYS-007
ENSP00000436654
ENST00000533874
H0YEV7 [Direct mapping]
Dihydropyrimidinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008152 [metabolic process]
GO:0016810 [hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds]
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 54 aa
6.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.