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A majority of malignancies showed weak to moderate cytoplasmic staining. Malignant gliomas, skin, prostate, cervical and endometrial cancers were mostly negative.
Most malignancies were moderately stained. Strong positivity was observed in ovarian cancers as well as several breast, colorectal, few endometrial cancers. A majority of testicular cancers were weakly stained or negative.
Majority of cancer tissues showed weak to moderate cytoplasmic positivity. Renal cell carcinomas and testis cancers were generally negative.
GENE INFORMATION
Gene name
EBAG9 (HGNC Symbol)
Synonyms
EB9, RCAS1
Description
Estrogen receptor binding site associated, antigen, 9 (HGNC Symbol)
Entrez gene summary
This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor, which binds to the estrogen-responsive element found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Alternate splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 10. [provided by RefSeq, Jul 2013]
O00559 [Direct mapping] Receptor-binding cancer antigen expressed on SiSo cells A0A024R9E0 [Target identity:100%; Query identity:100%] Estrogen receptor binding site associated, antigen, 9, isoform CRA_a
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SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O00559 [Direct mapping] Receptor-binding cancer antigen expressed on SiSo cells A0A024R9E0 [Target identity:100%; Query identity:100%] Estrogen receptor binding site associated, antigen, 9, isoform CRA_a
Show all
SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)