Expression of MAL2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	MAL2
Gene description	Mal, T-cell differentiation protein 2 (gene/pseudogene)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431, HaCaT, SK-BR-3)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in several tissues, most abundant in gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA043831
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable), renal cancer (favourable), endometrial cancer (unfavourable) and pancreatic cancer (unfavourable).
Breast cancer p<0.001 Renal cancer p<0.001 Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043831

GENE INFORMATION
Gene name	MAL2
Synonyms
Description	Mal, T-cell differentiation protein 2 (gene/pseudogene) (HGNC Symbol)
Entrez gene summary	This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface. [provided by RefSeq, Jul 2008]
Chromosome	8
Cytoband	q24.12
Chromosome location (bp)	119165034 - 119245673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000147676 (version 83.38)
Entrez gene	114569
UniProt	Q969L2 (UniProt - Evidence at protein level)
neXtProt	NX_Q969L2
Antibodypedia	MAL2 antibodies

PROTEIN BROWSER

MAL2-001	MAL2-003	MAL2-004	MAL2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAL2-001 ENSP00000479708 ENST00000614891	Q969L2 [Direct mapping] Protein MAL2 A0A024R9E4 [Target identity:100%; Query identity:100%] Mal, T-cell differentiation protein 2, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0045121 [membrane raft] GO:0048471 [perinuclear region of cytoplasm] GO:0070062 [extracellular exosome] Show all	176 aa 19.1 kDa	No	4
MAL2-003 ENSP00000483044 ENST00000522112	A0A087WZL1 [Direct mapping] Protein MAL2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	108 aa 12.1 kDa	No	2
MAL2-004 ENSP00000482729 ENST00000534619	A0A087WZL1 [Direct mapping] Protein MAL2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	108 aa 12.1 kDa	No	2
MAL2-005 ENSP00000484544 ENST00000531508	A0A087WZL1 [Direct mapping] Protein MAL2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	108 aa 12.1 kDa	No	2